Renal Endocrine Flashcards
1
Q
Aliskiren
A
- Blocks enzymatic activity of renin
- Decrease PRA
- Decrease AII, which causes decrease in aldosterone
2
Q
Amiloride
A
- aldosterone antagonist
- competitive inhibitor of ENaC, preventing sodium reabsorption
- works at CCT
- K+ sparing
- enhances Ca2+ reabsorption
3
Q
Metformin
A
- Diabetes drug
- Inhibits liver gluconeogensis
- Inhibits glucose absorption in intestines
- Promotes insulin uptake
4
Q
Thiazolidenediones
A
(Pioglitazone)
- diabetes drug
- increases sensitivity to insulin at target cells
5
Q
Sulfonylureas
A
- Diabetes drug
- targets pancreatic beta cells
- Increase production of insulin
6
Q
Fludrocortisone
A
-mineralocorticoid agonist (aldosterone agonist)
7
Q
Tolvaptan
A
- V2 receptor antagonist
- blocks effects of AVP (therefore prevents water and sodium) reabsorption
- given for SIADH, hyponatremia associated with CHF
8
Q
Furosemide
A
- loop diuretic
- works at TAL at NKCC, preventing reabsorption mediated by this channel
- Ca2+ wasting!
- potent, fast acting, and short half life
9
Q
HTCZ
A
- weak diuretic
- works at DCT at NCC, preventing Na+ and Cl- reabsorption
- first line of action for HTN
- K+ wasting
10
Q
ACE Inhibitors
A
- prils
- prevents production of AII
- therefore prevents vasoconstriction, prevents aldosterone secretion (prevents Na+ reabsorption)
11
Q
Amlodipine
A
- Ca2+ channel blocker
- prevents vasoconstriction
12
Q
ARB
A
- sartans
- block AT1 receptors
- block activity of AII (constriction of efferent arteriole, Na+ reabsorption, aldosterone secretion)
13
Q
Eplerenone and Spironolactone
A
- mineralocorticoid (aldosterone) receptor antagonist
- works at CCT
