Renal Embryology EC

Question 1

Pronephros, Mesonephros, and Metanephros

Answer 1

Pronephros= early kidney structure week 4 then degenerates

Mesonephros= functions as interim kidney for 1st trimester and later contributes to male genital system

Metanephros = permanent kidney structure. First appears in 5th week.

Question 2

Derived from caudal end of mesonephros. Gives rise to ureter, pelvises, calyces, and collecting ducts.

Answer 2

Ureteric bud

Question 3

Ureteric bud interacts with this tissue inducing differentiation and formation of glomerulus through distal convoluted tubule

Answer 3

Metanephric mesenchyme

Question 4

Most common site of obstruction (hydronephrosis) in fetus

Answer 4

Ureteropelvic junction (last to canalize)

Question 5

Oligohydramnios > compression of fetus > limb deformities, facial deformities, and pulmonary hypoplasia

Answer 5

Potter’s syndrome

Question 6

Due to abnormal interaction between ureteric bud and metanephric mesenchyme. This leads to a nonfunctional kidney consisting of cysts and CT.

Answer 6

Multicystic dysplastic kidney

If unilateral (most common), generally asymptomatic with compensatory hypertrophy of contralateral kidney.