Renal embryology Flashcards
Mesoderm has 3 parts - paraxial, intermediate plate and lateral plate
Which part do the kidneys and ureters develop from
intermediate plate
What is the allantois
Outpouching of endoderm in the hindgut region that extends into body stalk (future umbilical cord)
What is the cloaca
Future posterior opening of the GI tract, i.e. anal opening
Urogenital sinus derived from cloaca ultimately forms what (2)
urinary bladder + urethra
Cloaca (future posterior opening of GI tract) divides posteriorly and anteriorly into
Rectum - posterior
Urogenital sinus - anterior
Urogenital sinus is derived from the
cloaca
Kidneys and ureter develop form intermediate plate mesoderm but urinary bladder and urethra develop from what germ layer
endoderm
Intermediate plate mesoderm in week 4 becomes the
pronephros
Intermediate plate mesoderm in the NECK REGION in early week 4 becomes the pronephros which consists of (2)
pronephric duct + rudimentary pronephric tubules
Intermediate plate mesoderm in the TRUNK REGION in late week 4 becomes the
mesonephros
Pronephric duct becomes the what duct
mesonephric duct
Mesonephros functions as what for the first 4 weeks
kidneys
Mesonephros functions as the temporary kidneys for the first 4 weeks, then what starts to develop from week 5 to form the definitive kidneys
metanephros
Metanephros consists of (2)
Ureteric bud Metanephric mesoderm (caudal part of intermediate plate mesoderm)
What happens to the mesonephros after its function as the kidneys is taken over by the metanephros
incorporated into the developing sex organs –> repro system
Ureteric bud (part of metanephros) becomes what
renal pelvis/ureter
Ureteric bud (part of metanephros) branches to form what (4)
calyces
collecting duct
renal pelvis
ureter
Ureteric bud and metanephric mesoderm do what to each other
reciprocally induce each other to grow (ureteric bud becomes the ureter and metanephric mesoderm become the nephrons)
Nephron consists of (4)
Renal corpuscle + PCT + Loop of Henle + DCT
Uriniferous tubule = (2)
Nephron + Collecting duct
Nephron (renal corpuscle + PCT + Loop of Henle + DCT) derived from what
metanephric mesoderm
Calyces and collecting duct derived from what
ureteric bud
Kidneys ascend up abdomen until they come into contact with
adrenal glands
Mesonephric duct drains into
cloaca (future bladder)
Allantois (outpuching on endoderm in hindgut region) obliterates to form remnant known as
median umbilical ligament or embryonic urachus
Hilum of the kidneys rotate from ventrally to face
medially
