Renal dose adjustments

Question 1

Capecitabine

Answer 1

CrCl 30-50 mL/min= 25% decrease

CrCl <30 mL/min= do not use

Question 2

Carboplatin

Answer 2

Renal insufficiency=Calvert Formula

AUC (GFR+25)= total dose

Question 3

Cisplatin

Answer 3

Use with caution in patients with CrCl 1.5 mg/dL or CrCl <60 mL/min

Question 4

Cyclophosphamide

Answer 4

Renal failure= 25% decrease

Question 5

Topotecan

Answer 5

CrCl 20-39 mL/min= 50% decrease

CrCl <20 mL/min= Do not use