Hepatic dose adjustments

Question 1

Anthracyclines -rubicin

Answer 1

Bilirubin 1.2-3 mg/dl= 50% decrease
Bilirubin 3.1-5 mg/dl= 75% decrease
Bilirubin >5 mg/dl= Omit

Question 2

Docetaxel

Answer 2

Bilirubin >ULN
AST/ALT 1.5X ULN and Alk Phos >2.5x ULN
Do not give

Question 3

Paclitaxel

Answer 3

Use with caution in hepatic failure

Question 4

Vinblastine, Vincristine

Answer 4

Bilirubin 1.5-3 mg/dL=50% decrease

Bilirubin >3 mg/dL= omit

Question 5

Vinorelbine

Answer 5

Bilirubin 2.1-3 mg/dL= 50% decrease

Bilirubin >3 mg/dL= 75% decrease