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CSF3 Exam 3 > Renal Clearance- Lee > Flashcards

Renal Clearance- Lee Flashcards

1
Q

What substances should be normally 100% reabsorbed back into the blood?

A
  • glucose
  • amino acids
  • lactate
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2
Q

What are the two substance that have high clearance and are used to measure GFR and blood flow?

A
  • inulin
  • creatinine
  • Para-aminohippurate (PAH)
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3
Q

What is the significance of the value of renal clearance for molecules that once filtered, are neither reabsorbed or secreted? What are these molecules?

A

inulin
125 I-iothalamate
creatinine

Their renal clearance is equal to GFR.

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4
Q

How is clearance used to measure GFR?

A

GFR= (Urinary inulin concentration X urine flow rate)/ plasma inulin concentration

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5
Q

Theoretically, if a substance is completely cleared from

the plasma, its clearance rate would equal what?

A

renal plasma flow

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6
Q

It is the compound being used that will determine whether we’re measuring GFR of renal plasma flow. Below are a list of molecules that should be listed whether or not they are used to measure GFR or renal plasma flow.

  • inulin
  • 125 I-iothalamate
  • creatinine
  • Para-aminohippuric acid (PAH)
A

GFR

  • inulin
  • 125 I-iothalamate
  • creatinine

RENAL PLASMA FLOW
-Para-aminohippuric acid (PAH)

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7
Q

What is the normal GFR?

A

GFR = 125 ml/min = 180 liters/day

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8
Q

Plasma volume is filtered approximately how many times a day?

A

60 times per day

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9
Q

What is filtration fraction equal to and what is its value normally?

A

GFR/renal plasma flow

20%

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10
Q

Glomerular filtrate composition is about the same as plasma, except for what?

A

large proteins

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11
Q

What is the normal net filtration pressure?

A

10 mmHg

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12
Q

What is is the normal Kf and what parameters does it take into account?

A

12.5 mL/min per mmHg

surface area and hydraulic conductivity

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13
Q

What are diseases that can reduce Kf and GFR?

A
  • HTN
  • chronic DM
  • glomerulonephritis
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14
Q

Describe the renal handling of the four substances below.

  • inulin
  • glucose
  • Paraminohippuric acid (PAH) -
  • sodium
A

inulin: filtered only and excreted in the urine
glucose: filtered and completely reabsorbed

Paraminohippuric acid (PAH) - filtered and secreted

sodium: filtration and partial reabsorption

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15
Q

Typically, plasma concentration of creatinine is 1 mg/100mL given that GFR is 125 mL/min.
If plasma concentration of creatinine goes up and GFR goes down, what does this indicate?

A

decreased kidney function

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16
Q

What is the equation for renal clearance?

A

Renal clearance: (urine concentration of substance Y x urine flow rate)/ plasma concentration of substance Y

CSF3 Exam 3 (8 decks)

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