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Renal > Renal Cancer Pharmacology > Flashcards

Renal Cancer Pharmacology Flashcards

1
Q

Cisplatin MOA

A

Cross-links DNA

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2
Q

Cisplatin AE

A

Myelosuppression
Increased infection
Renal toxicity

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3
Q

Cyclophosphamide MOA

A

Covalently binds DNA

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4
Q

Cyclophosphamide AE

A

Hemorrhagic cystitis (take with MESNA to fight against Acrolein)

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5
Q

What other chemotherapy drug can cause hemorrhagic cystitis due to acrolein?

A

Ifosfamide

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6
Q

What is the MOA of Ifosfaide?

A

Nitrogen mustard alkylating agent

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7
Q

Doxorubucin MOA

A

generates free radicals and intercalates between DNA

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8
Q

Doxorubucin AE

A

Cardiotoxic (give with dexrazoxane)

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9
Q

Dactinomycin MOA

A

Antibiotic (S/G2 phase) that intercalates in DNA

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10
Q

Dactinomycin AE

A

Myelosuppression

Hepatic Dysfunction

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11
Q

Etoposide MOA

A

Inhibits topoisomerase II

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12
Q

Etoposide AE

A

Hematologic toxicity

BP instability

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13
Q

Vincristine MOA

A

Prevent mitotic spindle polymerization

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14
Q

Vincristine AE

A

SIADH
Neurotoxicity
“Stocking glove”

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15
Q

What do the rapamycins end in?

A

“olimus”

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16
Q

What is the MOA of rapamycins?

A

mTOR inhibitor

17
Q

Rapamycin AE

A 
Rash
Mucositis
Pulmonary Infiltrates
Anemia
CYP orally active!
18
Q

What do TKIs end with?

A

“ib”

19
Q

What is the MOA of TKIs?

A

Inhibit VEGFR, PDGFR, FGFR, Kit, Raf, etc

20
Q

What are the major adverse effects of TKIs?

A 
CV
Liver
Stevens-Johnson hypersensitivity
proteinuria
Endocrine dysfunction
CYP interactions
21
Q

Bevacizumab MOA

A

inhibits VEGF (no angiogenesis)

22
Q

Bevacizumab BBW

A

Hemorrhage
GI Perforation
Wound Healing Problems

23
Q

You commonly combind Bevacizumab with what to treat RCC?

A

IFN-alpha

24
Q

IFN-alpha MOA

A

JAK/STAT activation to increase transcription of anti-tumor activity

25
Q

IFN-alpha BBW

A

neuropsychiatric, autoimmune, ischemia/infectious disorders

26
Q

What is aldesleukin?

A

IL-2

27
Q

What is the MOA of aldesleukin?

A

T cell growth factor that stimulates body’s own immune system. LONG duration of action.

28
Q

Aldesleukin AE

A

VERY TOXIC: creates a state of septic shock (hypotension, tachycardia, BILATERAL pulmonary edema)

Renal (12 decks)

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