Renal Cancer Pharmacology Flashcards
Cisplatin MOA
Cross-links DNA
Cisplatin AE
Myelosuppression
Increased infection
Renal toxicity
Cyclophosphamide MOA
Covalently binds DNA
Cyclophosphamide AE
Hemorrhagic cystitis (take with MESNA to fight against Acrolein)
What other chemotherapy drug can cause hemorrhagic cystitis due to acrolein?
Ifosfamide
What is the MOA of Ifosfaide?
Nitrogen mustard alkylating agent
Doxorubucin MOA
generates free radicals and intercalates between DNA
Doxorubucin AE
Cardiotoxic (give with dexrazoxane)
Dactinomycin MOA
Antibiotic (S/G2 phase) that intercalates in DNA
Dactinomycin AE
Myelosuppression
Hepatic Dysfunction
Etoposide MOA
Inhibits topoisomerase II
Etoposide AE
Hematologic toxicity
BP instability
Vincristine MOA
Prevent mitotic spindle polymerization
Vincristine AE
SIADH
Neurotoxicity
“Stocking glove”
What do the rapamycins end in?
“olimus”
What is the MOA of rapamycins?
mTOR inhibitor
Rapamycin AE
Rash Mucositis Pulmonary Infiltrates Anemia CYP orally active!
What do TKIs end with?
“ib”
What is the MOA of TKIs?
Inhibit VEGFR, PDGFR, FGFR, Kit, Raf, etc
What are the major adverse effects of TKIs?
CV Liver Stevens-Johnson hypersensitivity proteinuria Endocrine dysfunction CYP interactions
Bevacizumab MOA
inhibits VEGF (no angiogenesis)
Bevacizumab BBW
Hemorrhage
GI Perforation
Wound Healing Problems
You commonly combind Bevacizumab with what to treat RCC?
IFN-alpha
IFN-alpha MOA
JAK/STAT activation to increase transcription of anti-tumor activity
IFN-alpha BBW
neuropsychiatric, autoimmune, ischemia/infectious disorders
What is aldesleukin?
IL-2
What is the MOA of aldesleukin?
T cell growth factor that stimulates body’s own immune system. LONG duration of action.
Aldesleukin AE
VERY TOXIC: creates a state of septic shock (hypotension, tachycardia, BILATERAL pulmonary edema)
