Renal and Urologic Problems Flashcards
Urinary Tract Infection: Bacterial Count
- Bacterial count of >10^5 CFU/mL
- 10^2 to 10^3 CFU/mL can also be indicative of UTI if present with signs and symptoms
- CFU - colony forming units
Most common pathogen of UTI
Escherichia cole (E. coli)
- also by fungal and parasites - uncommon
Upper UTI
renal parenchyma, renal pelvis, ureters
Lower UTI
bladder, urethra
Clinical Manifestations UTI (6)
- dysuria
- Fever (upper UTI)
- cloudy urine, hematuria
- hesitancy/urgency/frequency
- burning on urination
- upper UTI: flank pain, fever, chills
Diagnosis of UTI
- WBC and nitrites and leukocytesterase (enzyme produced by WBC) in the urinalysis
- Do a CNS after a urinalysis
Management of UTI
Health promotion (preventative)
Full course of antibiotics
Short term: 1-3 days
Longer term: 7-14 days (for UTI caused by obstructions or catheter. more complex)
Acute Pyelonephritis Pathophysiology
- inflammation of renal parenchyma & collecting system
- bacterial infection (most common cause)
- begins with infection of lower urinary tract
- often presence of pre-existing: vesico-ureteral reflux, dysfunction of lower urinary tract infection e.g BPH
Acute Pyelonephritis: clinical manifestations (5)
- flank pain, chills, costovertebral tenderness (where ribs and back meet)
- vomiting, nausea
Acute Pyelonephritis Treatment
mild vs severe
- mild - abx 14-21 days
- severe - hospitalized IV abx so it gets there quicker. Something for pain and fever. Analgesics and a follow-up culture
Chronic Pyelonephritis
- Shrunken kidney whose function is lost d/t scarring or fibrosis
- Outcome of recurring infection in upper urinary tract
- aka: interstitial nephritis, chornic atrophic pyelonephritis, or reflux nephropathy
- loss of functioning nephrons
- level of renal function varies depending on if 1 or both kidneys are involved
- Often progresses to end-stage renal disease
Urethritis
- inflammation of urethra from bacterial or viral infection
- usually from sexual transmission
- difficult to diagnose as urethral discharge may not be present in women
- treatment based on identifying & treating the cause and obtaining symptomatic relief
Purulent discharge in urethritis means:
gonococcal urethritis
Clear discharge in urethritis
non-gonococcal urethritis
Interstitial cystitis
a chronic, painful inflammatory disease of the bladder
Believed to be associated with autoimmune or allergic response
2 primary clinical manifestations of Interstitial Cystitis
pain
lower urinary tract symptoms
Diagnosis of Interstitial Cystitis
- cystitis suspected when pt experiences symptoms of a UTI despite absence of bacteriuria, pyuria, or a positive urine culture
- careful history and physical examination required