Renal acid and Base Control

Question 1

Acidemia

Answer 1

ICF takes in H+
=low ECF pH
pH<7.35

High H+ concentration buffered by raising ECF K+ concentration

Question 2

Alkalemia

Answer 2

ICF donates H+
=high ECF pH

pH>7.45

Low H+ concentration buffered by lowering ECF K+ concentration

Question 3

Phosphate Buffering of Secreted H+

Answer 3

The buffering of secreted H+ regenerates the plasma HCO3- that had be “consumed” elsewhere when the NaH2PO4 lost a H+ in a less acidic body compartment. It now carries that H+ into the urine

Question 4

Urine Acidification

Answer 4

“New” bicarb is generated during this process

Secreted H+ is buffered by NH3–>NH4+, phosphate, etc, for excretion while bicarb is reabsorbed