Immune Renal System

Question 1

Ischemic AKI

Answer 1

Leads to metabolic acidosis and ATP depletion

One of the major causes of acute renal failure (ARF)

Question 2

Causes of Kidney Hypoperfusion and AKI

Answer 2

Intravascular volume depletion and hypotension

Hepatorenal syndrome

Decrease effective intravascular volume

Meds

Sepsis

Renal vascular disease

Question 3

Damps

Answer 3

Intrinsic molecular patterns, aka alarmins

Immune cells recognize DAMPs via TLRs, become activated and induce innate immune responses