Renal Flashcards
What are the major functions of the kidneys?
- Control fluid and ion balance
- volume, osmolarity, pH, mineral composition
- remove wastes from circulation
- gluconeogenesis
- endocrine function/hormone
- fluid balance- Renin, prostaglandins, kinins
- RBC production- EPO
- bone- 1, 25 dihydroxyvitamin D3
Autoregulation
What do our anesthetic techniques cause?
- Autoregulation of RBF and GFR maintained with MAP between 80-180
- All agents and most techniques cause decreased:
- GFR
- UOP
- RBF
- electrolyte excretions
- All major kidney functions affected, usually reversible after procedure
What is considered oliguria?
What are the causes?
- UOP < 0.5 ml/kg/hr or < 30 ml/hr
- Prerenal
- hypovolemia
- decreased CO
- renal
- renal ischemia
- nephrotoxic drugs
- release of hemoglobin or myoblobin (in rhabdo, will clog glomeruli)
- Post renal
- bilateral ureteral obstruction
- extravasation due to bladder rupture
What affects do anesthetics have on normal renal function (hormone release)?
-
ADH release due to surgical stimulation
- will decrease UOP
- aldosterone release- from baroreceptor response to volume depletion
- Autoregulation may be affected under GA
Hypotension caused by agents under GA causeses blood to _____. What happens next?
- shunt away from the kidney
- any decrease in RBF causes release of Renin which leads to vasoconstriction and SNS stimulation further decreases RBF
Prostaglandins:
What do they do?
When are they produced?
What drug does affects prostaglandins?
- prostaglandins have protective effect agains renal ischemia (local vasodilators)
- oppose the actions of angiotensin II, SNS, ADH to balance the decrease in RBF and increase UOP
- Production of prostaglandins is promoted in renal ischemia, renal hypotension, and physiologic stress
- Ketoralac should be avoided in pts a risk for medullary ischemia because it inhibits the productions of prostaglandins, increasing risk of ischemic damage
Does Low dose dopamine decrease ARF?
dose
NO. It does not decrease incidence of ARF, dialysis, or mortality, but it does have inotropic effects with diuretic activity.
Does not protect the kidney b/c it does not increase BF to the deep loops of henle where the metabolic demand is.
1-2 mcg/kg/min
What does spinal and epidural anesthesia do to Renal function?
- T4-T10 sympathectomy will decrease release of catecholamines, renin, and vasopressin
- Key to maintenance of renal blood flow and GFR is you have to maintain renal perfusion pressure
- fluid boluses
What VA do we avoid with renal patients? Why are these agents more concerning?
- Methoxy > Enflurane > Maybe Sevo
- these agents create free fluoride ions during metabolism that can cause tubular injury and the loss of concentrating ability
Which VA are very low risk to the kidney?
- Isoflurane and Desflurane
What is the most up to date rule regarding Sevo flows?
- FDA recommends flows of 2L
- if running 1-2 L, should not use for more than 2 MAC hours
- no clinical evidence of injury from compound A
How do PIP and PEEP affect the kidney?
how can these changes be overcome?
- The higher the PIP and PEEP, the greater the decrease in RBF, GFR, and Urine flow rate
- Hydration will overcome these changes by improving CV function
What response would you expect the body to have to a decreased preload, CO, and arterial hydrostatic pressure
- SNS activation
- RAAS activation
- promotion of vasopressin release
What are the clinical features of Chronic Renal failure?
- long term dialysis is required when Cr > 3 mg/dl (GFR < 30 ml/min)
- Generalized edema- may need to administer higher doses of water soluble drugs
- high concentrations of non-protein nitrogens
- creatinine, urea, uric acid
- High concentration of phenols, sulfates, phos, and potassium
- Osteomalacia- vit D must be converted by liver and kidneys before it is able to promote Ca absorption
- Pruritis
Why are renal pts anemic?
What Hgb is normal for a renal pt?
what are the Hgb/Hct goals for these pts
- Anemic because of decreased production of EPO
- EPO therapy is helpful in improving this anemia, however it causes HTN or makes current HTN worse
- Hgb 5-8 g/dl
- Goal:
- Hct 36-40%
- Hgb> 12 g/dl in females and >13 g/dl in males