Pain Flashcards

1
Q

What is acute pain?

A
  • Caused by tissue damage– it is a protective response
    • Peripheral nociceptive neuron is stimulated by intense noxious stimuli which sends a signal to the CNS
  • CNS: brain and spinal cord process the afferent input and this results in sensation of pain
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2
Q

What is chronic pain?

A
  • Neural dysfunction in the peripheral and/or CNS pain pathways
  • extends beyond the expected 3-6 months healing period and often has no identifiable cause
    • serves no purpose
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3
Q

What are the consequences of pain?

A
  • Activation of stress response- SNS and adrenocortical stimulation
  • elevated blood sugar
  • immunosuppression
  • urinary retention
  • altered coagulation
  • psychosocial- anxiety, depression, impact of relationships and productivity
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4
Q

What makes pain assessment difficult?

A
  • It is difficult because it is subjective and each patient’s experience of pain is unique
  • Pain can be influenced by:
    • unique physiology (PNS and CNS circuitry)
    • pathophysiology
    • personality
    • previous life experience
    • cultural and religious background
    • age
  • Healthcare providers may undertreat pain if:
    • they dont believe the pt
    • they dont understand the science behind it
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5
Q

What should you assess regarding the history of pain?

A
  • existence of pain
    • assess each type of pain/pain problem separately
  • previous injuries
  • Adjunctive therapies
    • acupuncture, TENS, injection therapy, SCS
  • Coexisting psychological disease/physical disease
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6
Q

What are the elements of a pain assessment?

A
  • P- precipitating events
  • Q- quality
  • R- Region/radiation
  • S- severity
  • T- Temporal relationship/Timing
  • A- associated symptoms
    • functional impairment
    • previous treatment
    • inflammation
  • Pain goals
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7
Q

What is the benefit of behavioral pain scales?

A
  • provides a means for consistent evaluation of pain in non-verbal patients
    • pediatric pts
    • pts with cognitive impairment
    • critically ill patients
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8
Q

What pain scale would be appropriate for a pediatric patient >3 yrs old?

A
  • Wong-Baker FACES scale
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9
Q

What is the Payen Behavioral pain scale?

A
  • It was developed for critically ill intubated ICU patients
  • Is reliable and valid and correlates to NPI ratings, even in patients who are on sedation
  • uses a 0-12 pain rating scale
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10
Q

For what patients would you use the FLACC score?

A

2 months to 7 years

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11
Q

For what patients would you use the CRIES pain scale?

A

0-6 month olds

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12
Q

What else should you assess in a patient with chronic pain?

A
  • General medical history- comorbidities contributing to complex pain condition
  • How does pain effect:
    • sleep?
    • physical functions?
    • ability to work?
    • your mood?
    • family/social life?
  • What treatments have you received? Effects? adverse effects?
  • Are you depressed
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13
Q

What should you assess on the physical exam of pain?

A
  • General physical examination
  • affected area
  • neurological exam
  • musculoskeletal system
    • ROM
    • muscle wasting
  • skin- redness, wounds, edema, changes
  • assessment of psychological factors: un-kept personal hygiene
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14
Q

What are some specific diagnostic studies that can be done?

A
  • Quantitative sensory testing for pain thresholds and pain tolerance
  • diagnostic nerve blocks
  • pharmacologic tests
  • conventional radiography, tomography, MRI, ultrasound imaging
  • Electromyography nerve test (EMG)- assess nerve impulses into muscle
  • Nerve conduction velocity test (NCV)- to see how rapid an impulse comes through a nerve
  • bone scans- cancer pain
  • blood test- looking for comorbidites
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15
Q

How can you test for different types of allodyna?

A
  • “poor man’s sensory testing”
  • Cold allodynia- cold water in a glass tube
  • heat allodynia- glass tube with warm water
  • dynamic mechanical allodynia- cotton wool and artist’s brush
  • hyperalgesia- blunt needle
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16
Q

What is the neuroendocrine response that is caused by acute pain?

A

An SNS response, release of cortisol and Renin

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17
Q

What may be a predictor of chronic pain?

A

Poorly controlled acute pain

18
Q

What ways may cancer cause pain?

A
  • By the cancer
    • tumor invading bone (most common)
    • tumor compressing peripheral nerves
  • Pain due to treatment
  • Physical effects- pain can worsen due to loss of sleep, appetite, nausea, and vomiting
  • Psychological- pain can worsen with heightened anxiety, feelings of loss, low self-esteem, changes in life goals, disfigurement
19
Q

Why is it important to manage post-operative pain?

A
  • Reduces stress response
  • shorter times to extubation, shorter ICU stay
  • improved respiratory function
  • earlier return of bowel function
  • early mobilization, decreased risk of DVTs
  • early discharge
  • patient satisfaction
  • reduction in sensitization, neuroplasticity, wind-up phenomenon and transition to chronic pain
20
Q

What is the wind-up phenomenon?

A
  • The idea that pain will increase when a stimulus is delivered repeatedly above a critical rate
  • Caused by repeated stimulation of C fibers
21
Q

What is preemptive analgesia?

A
  • Blockade of response to noxious stimuli and extending this block into the postoperative period
  • Reduced post-op pain and accelerates recovery
  • Thought to stop peripheral and central sensitization and hyperexcitability to pain and therefore the development of chronic pain
22
Q

What is the principle of the multimodal approach?

A
  • Control postoperative pain and attenuate the perioperative stress response through the use of regional anesthetic techniques and a combination of analgesic agents (multimodal analgesia)
  • It is an extension of “clinical pathways” into effective postoperative rehabilitation pathways
23
Q

What are the ERAS protocols regarding pain?

A
  • Early Recovery After Surgery
  • Pre-hospital: make a pain management plan
  • Pre-op: initiation of multimodal medications and regional block placement
  • Intra-op: short-acting, opioid-sparing medications; multimodal medications; regional
  • Post-op: regional analgesia, non-opioid analgesics/NSAIDS
24
Q

What are the different modes of drug administration?

A
  • IV- preferred
  • SC
  • IM
  • Oral
  • SL
  • PR
  • Buccal
  • intranasal
  • transdermal patch
  • *ketamine nebulizers or gargles- have a systemic effect
25
Q

Opioids

how do they work?

advantages

disadvantages

A
  • Were the standart in pain managment
  • Work by affecting mu and kappa opioid receptors in the CNS
  • Adv: no analgesic ceiling
  • Disadv: side effects
    • respiratory depression
    • hypotension
    • N/V
    • sedation
    • pruritus
    • urinary retention
    • dependence
26
Q

How do NSAIDS work?

When is it used?

A
  • Analgesic effect achieved through inhibition of cyclooxygenase (COX), preventing the synthesis of prostaglandins
    • results in the attenuation of the nociceptive response to inflammatory mediators
    • peripherally and in the spinal cord
  • Used in mild to moderate pain and pain related to inflammatory conditions
    • useful in adjunct to opioids
27
Q

Side effects of NSAIDS?

A
  • Renal dysfunction
  • GI hemorrhage
  • effects on bone healing/osteogenesis
  • liver dysfunction
  • decreased homeostasis
    • platelet dysfunction
    • inhibition of thyromboxane A2
28
Q

What are some NSAIDS?

A
  • Ketorolac
  • piroxicam (Feldane)
  • Nabumatone (Relafen)
  • Indomethacin (Indocin)
  • Celecoxib (Celebrex)
  • Parecoxib
  • Caldolor (ibuprophen)
29
Q

What are some adjubant drugs that can help treat pain?

A
  • Ketamine- IV, gargled, nebulized
  • Nalbuphine (nubain)- IV
  • Lortab elixir (hydrocodone and acetaminophen)- PO
  • Gabapentin (Neurontin)- PO
  • Mag sulfate- PO, IV
  • Lidocaine lollipops
  • lidocaine infusions
  • Beta blockers
  • Corticosteroids
30
Q

What are the benefits of peripheral nerve blocks?

A
  • Single injection or continuous infuison
  • can be used intraoperatively or as an adjunct to postoperative analgesia
  • limits the path of nociceptive impulses
  • superior analgesia
  • few side effects
  • can have analgesia for up to 24 hours after singel injection
31
Q

What are the benefits of neuraxil analgesia?

A
  • provide superior analgesia compared with systemic opioids
  • reduced stress response
  • facilitates return of GI motility
  • decreased incidence of pulmonary complications
  • decreased incidence of coagulation-related adverse events
32
Q

Neuraxial opioids:

Difference between hydrophilic and lipophilic opioids

A
  • Hydrophilic opioids:
    • morphine and dilaudid
    • tend to remain within the CSF
    • delayed onset of action
    • longer duration
    • extensive CSF spread
    • high incidence of side effects
  • Lipophilic opioids
    • Fentanyl and sufentanyl
    • Rapid onset of action
    • shorter duration
    • minimal CSF spread due to segmental analgesic effect
    • less side effects
33
Q

What do you need to consider regarding Continuous epidural analgesia?

A
  • Choice and dose of analgesic agents
  • location of catheter placement
  • onset and duration of perioperative use
  • side effects and risks
  • availability of pain management personnel
34
Q

Regarding Analgesic agents for epidural:

LAs only

Opioids only

LAs combine with Opioids

A
  • LAs only
    • high failure rate
    • high incidence of motor blockade- d/t density required to have effect
    • hypotension common
  • Opioids only
    • Avoids motor block
    • less hypotension
    • side effects: resp dep, pruritis
  • Combined LA and opioids
    • Better choice for epidural
    • limits regression of sensory block
    • less motor block
    • decreases total dose of LA
    • great choice for abdominal, pelvic, thoracic, orthopedic procedures of lower extremeties
35
Q

What are some of the epidural drugs?

A
  • LAs
    • lidocaine
    • bupivicaine
    • ropivacaine
  • Opioids
    • morphine
    • dilaudid
    • fentanyl
    • sufentanyl
36
Q

What are some adjuvant neuraxil drugs?

how do they work?

limits?

A
  • Clonidine
    • selective alpha 2 agonist
    • prolongs duration of block
    • limited by side effects:
      • hypotension, bradycardia, sedation
  • Epinephrine and Neosynephrine
    • prolongs duration and intensity of block
37
Q

Medication related side effects of neuraxial analgesia

A
  • Hypotension
  • motor blockade
  • N/V
  • pruritis
  • respiratory depression
  • urinary retention
38
Q

What are the risks of epidural analgesia?

A
  • complications with placement
    • epidural hematoma
    • abscess
    • neurologic injury
  • Intravenous, entrathecal, or subcutaneous injection of medications
  • anticoagulants:
    • post-op surgical anticoagulants
39
Q

What are some adjunct treatments for acute pain?

A
  • Ice
  • surgical
    • local infiltration
    • intra-articular analgesia
    • pain pumps
  • TENS
  • acupuncture
  • psychological approaches
    • hypnosis
    • distraction
    • relaxation
    • imagery
    • music
40
Q

What are the advantages of a PCA?

A
  • cost-effective
  • higher degree of patient satisfaction
  • total drug consumption is less
  • harder to overmedicate self
  • prevents the pain-no pain cycle