Renal 5 - Drug therapy ( check PM2C)

Question 1

what does nephrotoxic drug mean?

Answer 1

Nephrotoxic drugs = drugs that have the potential to harm the kidneys

Question 2

what are the options which are available when reviewing medication in patients with AKI/CKD?

Answer 2

• stop the drug
• withhold the drug
• amend dose
• continue

Question 3

If your patient has reduced renal function you need to think about the following

Answer 3

• is the patient in AKI or CKD?
  
  • is the patient at risk of AKI?
  • which medications should be suspended?
  • which medications should we use with caution?
  • are there any alternative therapeutic options?
  • what dose should a medication be reduced to?
  • what additional monitoring do we need to do?
  • what are the pharmacokinetics of the drug?
  • what are the pharmacodynamics of the drug?

Question 4

pharmaokenetics : ADME

Answer 4

Absorption
Distribution
Metabolism
Excretion

Question 5

how can absorption of a drug be effected? (renal)

Answer 5

Patients with renal failure typically have oedema as their kidneys are less efficient at removing water and salt

Oedema can affect the wall of the bowel

This may lead to reduced absorption of drugs