Renal 3 & 4 Flashcards
The glomerulus filters neutral molecules smaller than __ Angstroms (A), but nothing larger than __A
- 20
- 42
Are cationic or anionic molecules filtered more easily?
-cationic
Glomerular Hydrostatic Pressure
- Afferent end : 60 mmHg
- Efferent end : 58 mmHg
Bowman’s Oncotic pressure
- Afferent end : 0
- Efferent end : 0
Bowman’s Hydrostatic Pressure
- Afferent end : (-15 mmHg)
- Efferent end : (-15 mmHg)
Glomerular Oncotic Pressure
- Afferent end: (-28 mmHg)
- Efferent end: (-35 mmHg)
Ways to change the Glomerular hydrostatic pressure and GFR
- change resistance at afferent end
- change resistance at efferent end
- increase blood pressure
Outcomes of Glomerulonephritis
- early stage: lower oncotic pressure of glomerular capillary, which increases GFR
- late stage: causes hydrostatic pressure in bowman’s space, which lowers GFR
Outcome of Kidney Stones
-causes hydrostatic pressure in bowman’s space, which lowers GFR
Outcome of Nephritic syndrome
-higher glomerular permeability leads to proteinuria
What happens to pressure across renal artery to renal vein?
decreases
Where is the largest pressure drop?
afferent and efferent arterioles
Why does oncotic pressure increase in glomerular capillaries?
concentration of plasma proteins during filtration
Why does oncotic pressure decrease in peritubular capillaries?
dilution of plasma proteins during reabsorption
autoregulatory range spans arterial pressures from
100 to 180 mmHg
Renal shutdown occurs at arterial pressures under:
70 mmHg
-no GFR, but kidney still perfused
Renal Plasma Threshold (RPT)
point where glucose first appears in urine
Splay for Glucose represents
the Renal Plasma Threshold being reached before the transport maximum is reached. Indicated by glucose being excreted before transporter is working at maximum
Splay for PAH represents
the RPT being reached before maximum secretion rate is reached. Indicated by filtration before secretion rate is at the maximum.
