Renal Flashcards
Cancer that is 6th most common in males ?
Renal cell carcinoma
Male to female ratio for renal cell carcinoma
2:1
Incidence b/w ages of renal cell carcinoma?
55 and 75 yrs
Uncommon in ages less than?
45
Mutation in these two genes can cause RCC?
VHL & FLCN
Birt Hogg dube syndrome is caused by mutation in which gene?
FLCN gene
Most cases of RCC are _________?
Sporadic
In Von hippel -Lindau syndrome the kidney tumor type is?
Clear cell
In Hereditary leiomyomatosis and RCC the protein that plays a role in causing this disease is?
Fumarate hydratase
Birt Hogg dube syndrome is caused by mutation in which protein?
Folliculin
Tuberous sclerosis is caused by mutation in which protein?
Hemartin tuberin
Kidney tumor type in HLRCC is?
Papillary nonntype1
In Hereditary Papillary RCC has which kidney tumor cell type?
Papillary type1
This type of carcinoma is found in 80% of the patients who developed metastases?
Clear cell
This type of carcinoma is very aggressive and is associated with sickle cell trait.
Renal medullary carcinoma
This type of carcinoma shows predominant histology in children?
MITF translocation
RCC is known as _________ tumor?
Internists
Clinical presentation in RCC?
Hematuria
Palpable mass
Flank and abdominal pain
Etc
Most common sites of distant metastases inRCC.
Lungs, lymph nodes, liver, bone and brain
Treatment for stage 1 RCC.( Local tumor)
Radical or partial nephrectomy ( stage 1 &2)
Nephrectomy is done in which stage of RCC?
Stage 4
Mainstay of care of metastatic disease?
Systematic therapy
