Renal

Question 1

Cancer that is 6th most common in males ?

Answer 1

Renal cell carcinoma

Question 2

Male to female ratio for renal cell carcinoma

Answer 2

2:1

Question 3

Incidence b/w ages of renal cell carcinoma?

Answer 3

55 and 75 yrs

Question 4

Uncommon in ages less than?

Answer 4

45

Question 5

Mutation in these two genes can cause RCC?

Answer 5

VHL & FLCN

Question 6

Birt Hogg dube syndrome is caused by mutation in which gene?

Answer 6

FLCN gene

Question 7

Most cases of RCC are _________?

Answer 7

Sporadic

Question 8

In Von hippel -Lindau syndrome the kidney tumor type is?

Answer 8

Clear cell

Question 9

In Hereditary leiomyomatosis and RCC the protein that plays a role in causing this disease is?

Answer 9

Fumarate hydratase

Question 10

Birt Hogg dube syndrome is caused by mutation in which protein?

Answer 10

Folliculin

Question 11

Tuberous sclerosis is caused by mutation in which protein?

Answer 11

Hemartin tuberin

Question 12

Kidney tumor type in HLRCC is?

Answer 12

Papillary nonntype1

Question 13

In Hereditary Papillary RCC has which kidney tumor cell type?

Answer 13

Papillary type1

Question 14

This type of carcinoma is found in 80% of the patients who developed metastases?

Answer 14

Clear cell

Question 15

This type of carcinoma is very aggressive and is associated with sickle cell trait.

Answer 15

Renal medullary carcinoma

Question 16

This type of carcinoma shows predominant histology in children?

Answer 16

MITF translocation

Question 17

RCC is known as _________ tumor?

Answer 17

Internists

Question 18

Clinical presentation in RCC?

Answer 18

Hematuria
Palpable mass
Flank and abdominal pain
Etc

Question 19

Most common sites of distant metastases inRCC.

Answer 19

Lungs, lymph nodes, liver, bone and brain

Question 20

Treatment for stage 1 RCC.( Local tumor)

Answer 20

Radical or partial nephrectomy ( stage 1 &2)

Question 21

Nephrectomy is done in which stage of RCC?

Answer 21

Stage 4

Question 22

Mainstay of care of metastatic disease?

Answer 22

Systematic therapy