Renal Flashcards
What is the primary function of the renal and urinary system?
homeostasis
kidney’s specific role in homeostasis
regulating fluid and electrolytes, removing wastes, and providing hormones that are involved in red blood cell (RBC) production, bone metabolism, and blood pressure.
each kidney has how many nephrons
1 million
purpose of nephrons
filters blood
purpose of the glomerulus
filtration of waste
what can alter filtration
Increases in the glomerular capillary hydrostatic pressure cause increases in net filtration pressure and GFR
increases in Bowman space hydrostatic pressure causes decreases in filtration pressure and GFR
a substance moves from the filtrate back into the peritubular capillaries or vasa recta
tubular reabsorption
a substance moves from the peritubular capillaries or vasa recta into tubular filtrate
tubular secretions
What are some substances that should not be found in urine and why?
no protein = damage happens quickly to kidneys
no glucose in urine = diabetes
blood = internal bleeding
measuring the ratio of the amount of solutes (milliosmoles) to water using liters
osmolarity
calculates the ratio of the amount of solutes (milliosmoles) to water using weight or kilograms
osmolality
percentage of K filtered through the kidneys
90%
how is water regulated by kidneys
ADH/vasopressin
volume of electrolytes excreted each day by the kidneys
excretion is equal to intake per day
regulation of acid base balance by the kidneys
filtering bicarbonate and phosphate
results in metabolic acidosis
vessels constantly monitor blood pressure as blood begins its passage into the kidney
vasa recta
specialized juxtaglomerular cells near the afferent arteriole, distal tubule, and efferent arteriole secrete the hormone:
renin
Why is (MAP- Mean arterial pressure) important?
MAP of 65 maintains renal perfusion
how do kidneys regulate RBCs
releasing erythropoietin - which stimulates bone marrow to produce RBCs
purpose fo regulation of Vit D
production of calcium from active form of Vit D
purpose of prostaglandins
vasodilatory effects and important in maintaining renal blood flow
kidneys function of regulating waste
kidney is main excretory organ, eliminating body’s metabolic waste product
assessment involved for renal/urinary tract
Health History
Social History
Recognize cues (subjective data)
Costovertebral angle
labs for renal/urinary tract
Urinalysis and Urine Culture
Renal clearance
Creatinine clearance
Creatinine level (0.6- 1.2)
BUN (7-20)
GFR 120- 130mL/min
diagnostics for renal
Imagining
Ultrasounds
Urologic Endoscopic
Bladder Scan
what is post void residual
amount of urine left in bladder after urinating
what do we want a PVR to be
less than 50
less than 350
progressive loss of kidney (nephron) function
kidney disease 1
percentage of those with CKD that do not know
70%
nephron level classification for kidney disease
nephron functioning less than 20%
risk factors for kidney disease
diabetes and HTN
proteinuria
greater than 60 YO
family history
GFR indication for end stage renal disease
less than 15
clinical manifestations of CKD
hypertension
heart failure
hyperkalemia
metabolic acidosis
pulmonary edema
edema
uremia
GI and neuro symptoms
anemia
skeletal buffering
hypocalcemia
hyperphosphatemia
hyperparathyroidism
osteodystrophies
diagnostic testing for CKD
Lab work/ Urine Studies
K+ - hyperkalemia
Creatinine clearence – excreted in urine
Creatine level – 0.6-1.2
Hgb
BUN (7-20)
Magnesium
GFR – 120-130
Renal Ultrasound
Renal Biopsy –risk for bleeding
CT scan
medicatoins for CKD treatment
Sodium Polystyrene (Kayexalate) - Patiromoer (Veltassa) – decrease K
ACE Inhibitors and ARBs –lower BP
Svelamer carbonate (Renvela) - Calcium Acetate (PhosLo) – lowers phosphate
Calcium and Vit D – supplementation
Cinacalcet (Sensipar)
Exogenous Erythropoietin - Epogen, Procrit
Iron – reproduce RBC
Statins (Atorvastatin-Lipitor)
Gemfibrozil (Lopid) -cholesterol – build up – stops blockages
medications for CKD to decrease potassium
Sodium Polystyrene (Kayexalate)
Patiromoer (Veltassa)
medications for CKD to lower BP
ACE inhibitors
ARBs
medications for CKD to lower phsophate
Svelamer carbonate (Renvela)
Calcium Acetate (PhosLo)
medications for CKD to supplement
calcium
Vit D
medications for CKD to treat hyperparathyroidism
Cinacalcet (Sensipar)
medications for CKD to reproduce RBCs
Exogenous Erythropoietin
Epogen
Procrit
Iron
medications for CKD to lower cholesterol building and stop blockages
Statins (Atorvastatin-Lipitor)
Gemfibrozil (Lopid)