Renal Flashcards
What are the leading causes of kidney dz
Diabetes and hypertension
What is an eGFR
eGFR is a serum test to assess the amount of plasma filtered through the glomeruli (how well your kidneys are filtering)
What is a normal eGFR
GFR of 90 or higher
What is CrCl
Is a timed urine test to test the amount of creatinine the kidneys can clear in 24-hours
What is the reason for CrCl
Results shows how much creatinine has passed through your kidneys into your urine
Helps show how well your kidneys are removing the waste products from your blood
Normal CrCl
Less than 30 mg/g
What is azotemia
Biochemical abnormality, defined as elevation or buildup of, nitrogenous products, creatinine in the blood, and other secondary waste products within the body
Normal BUN and creatinine levels
Creatinine: 0.6-1.2
BUN: 7-21
What is acute kidney injury
Rapid loss of renal function due to damage to the kidneys
50% or greater increase in serum creatinine above baseline
Caused of AKI
Hypovolemia
Hypotension
Reduced cardiac output and HF
Obstruction of the kidney or lower urinary tract
Obstruction of renal arteries or veins
Categories of AKI
Prerenal: volume depletion, impaired cardiac efficiency, vasodilation
Intrarenal: renal ischemia, nephrotoxins, infection
Postrenal: urinary tract obstruction
Phases of AKI
Initiation: initial insult
Oliguria: increase in urea, creatinine, uric acid, phosphorous, potassium, magnesium
Diuresis: gradual increase in urine but GFR may still be abnormal
Recovery: improved renal function, may take 3-12 months
What is the most accurate indicator of fluid status
Weight
1 kg = 1000 mL
What is oliguria
Less than 400 mL in 24 hr
What is chronic kidney dz
Umbrella term that describes kidney damage or decreased GFR lasting 3 or more months
Prolonged acute inflammation
Can be subtle systemic manifestations
Causes of CKD
DM
HTN
Chronic glomerulonephritis
Pyelonephritis or other infections
Obstruction of urinary tract
Hereditary lesions
Vascular disorders
Medications or toxic agents
What is nephrosclerosis
Hardening of renal arteries (expected with aging)
Major cause of CKD
What is acute nephritic syndrome
Postinfectious glomerulonephritis, rapidly progressive glomerulonephritis, and membranous glomerulonephritis