Regulations Flashcards
According to the AABB Standards an order for blood products must be legible and have at least what two patient identifiers?
First and last name, unique patient identification number
Segments from transfused RBC units and the recipient’s blood specimen must be stored…
At 1-6 C for at least 7 days.
Antibodies enhanced by enzyme treatment
P1, Rh, Le(a), Le(b), Jk(a), Jk(b), I, i, ABH
Antibodies denatured by enzymes
M, N, S, Fy(a), Fy(b), Fy6, Ch(a), Rg(a), JMH, In(b), Yt(a), Pr, Tn, Xg(a), Gerbich 2 and 4, Cromer
Antibodies not readily denatured by enzymes
s, U
Antibodies unchanged by enzymes
Kell, Lutheran, Gerbich 3
Prior to sending a unit of RBC out for transfusion it must be retested to:
Confirm ABO typing and confirm Rh typing of Rh-neg units.
How does LISS enhance antibody uptake?
Reducing zeta potential and allowing increased attraction between positively charged antibodies & negatively charged red cells.
How does PEG enhance antibody-antigen binding?
Excluding water from around the red cells effectively concentrates the antibody and favors binding to targets.
How does polybrene enhance antibody uptake?
Enhances the formation of linked lattice by neutralizing the negative charges of the sialic acid residues on red cells allowing RBCs to come closer together.
How does albumin act as a potentiator of antibody-antigen interaction?
Enhances linked lattice formation by reducing the net negative charge of the red cells allowing them to come closer together.
How does enzyme treatment enhance some types of antibody-antigen interation?
Enhances the linked lattice formation by decreasing the net negative charge of red cells by removing sialic acid residues -> red cells can come closer together.
What is the frequency of Fy(a) negative white donors?
35%
What is the frequency of K negative white donors?
91%
What is the frequency of Jk(b) negative white donors?
28%
