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TM Boards > Protein-based Blood Group Antigens > Flashcards

Protein-based Blood Group Antigens Flashcards

1
Q

The gene Aquaporin-1 encodes the channel forming integral protein CHIP-1 which carries which blood group antigens?

A

The Colton blood group antigens, Co(a) and Co(b)

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2
Q

The Kidd blood group antigens, Jk(a) and Jk(b) are carried by what protein?

A

The human erythroid urea transport protein HUT11

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3
Q

What laboratory condition can red cells with the rare null phenotype in the Kidd system, Jk(a-b-), withstand?

A

Resist lysis in 2M urea

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4
Q

The Cartwright antigens, Yt(a) and Yt(b) are located in what protein?

A

Acetylcholinesterase (AChE). It’s function in erythrocytes is unknown. AChE is linked to the red cell membrane through a glycosylphosphatidylinositol (GPI) linkage

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5
Q

The Cromer antigens are located on what protein?

A

DAF/CD55. It is linked to the red cell membrane through a GPI linkage

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6
Q

Erythrocytes of patients with paroxysmal nocturnal hemoglobinuria (PNH) exhibit deficiency of…

A

GPI-linked proteins resulting in a lack of Cromer, Cartwright, Dombrock blood group antigens and John Milton Hagen (JMH) antigen.

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7
Q

Phenotype of Cromer-negative individuals

A

Increased sensitivity to complement-mediated lysis

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8
Q

What is the function of the Duffy (Fy) protein?

A

Chemokine receptor for IL-8, RANTES, MGSA and MCP-1. It may allow red cells to function as scavengers of excels chemokines in circulation.

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9
Q

What is the function of the Knops blood group antigen?

A

Complement component C3b/C4b receptor type 1 (CR1)

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10
Q

What is the function of the Indian blood group antigen?

A

Lymphocyte homing receptor/hyaluronan receptor, CD44 adhesion molecule

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11
Q

What is the function of the Kidd blood group antigen?

A

Human erythroid urea transporter proteins

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12
Q

What is the function of the Colton blood group antigen?

A

Human erythroid water transporter proteins

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13
Q

What is the function of the Diego and Wright blood group antigen?

A

Band 3 protein-Anion exchange

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14
Q

What is the function of the Chido/Rogers blood group antigen?

A

Complement component 4 (C4)

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15
Q

What is the function of the Cromer blood group antigen?

A

Decay accelerating factor (DAF)/CD55

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16
Q

What is the function of the Gerbich blood group antigen?

A

Glycophorin C and D

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17
Q

What red cell antigens serve as the receptor for Plasmodium sp?

A

Duffy, Cad, MNSs

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18
Q

What red cell antigen serve as the receptor for Parvovirus B19?

A

P

19
Q

What red cell antigen serve as the receptor for Polio virus?

A

Indian

20
Q

What red cell antigen serve as the receptor for E. coli, coxsackie virus and echovirus?

A

Cromer

21
Q

What red cell antigen serve as the receptor for Haemophilus influenzae?

A

Anton (AnW)

22
Q

What is the frequency of RhD in whites and blacks?

A

86% in whites, 92% in blacks

23
Q

What is the frequency of Rh antigen C in whites and blacks?

A

70% in whites, 33% in blacks

24
Q

What is the frequency of Rh antigen E in whites and blacks?

A

30% in whites, 21% in blacks

25
Q

What is the frequency of Rh antigen c in whites and blacks?

A

80% in whites, 97% in blacks

26
Q

What is the frequency of Rh antigen e in whites and blacks?

A

98% in whites, 99% in blacks

27
Q

List the observed frequency of Rh haplotypes in whites from greatest to least.

A

R1 (42%)&raquo_space; r (37%)&raquo_space; R2 (14%)&raquo_space; R0 (4%)&raquo_space; r’ (2%)&raquo_space; r’’ (1%), RZ and ry are very rare

28
Q

List the observed frequency of Rh haplotypes in blacks from greatest to least.

A

R0 (44%)&raquo_space; r (26%)&raquo_space; R1 (17%)&raquo_space; R2 (11%)&raquo_space; r’ (2%), RZ, r’’ and ry are very rare

29
Q

What antigens are present with R1 phenotype?

A

D, C, e

30
Q

What antigens are present with R2 phenotype?

A

D, c, E

31
Q

What antigens are present with R0 phenotype?

A

D, c, e

32
Q

What antigens are present with RZ phenotype?

A

D, C, E

33
Q

What antigens are present with r’ phenotype?

A

C, e

34
Q

What antigens are present with r’’ phenotype?

A

c, E

35
Q

What antigens are present with r phenotype?

A

c, e

36
Q

What antigens are present with rY phenotype?

A

C, E

37
Q

Alloimmunization is observed in up to what percentage of sickle cell patients?

A

30%

38
Q

What are the most common blood group antibodies detected in sickle cell patients?

A

Anti-C, anti-E and anti-K

39
Q

Why are anti-C, anti-E and anti-K the most common antibodies observed in sickle cell patients?

A

They are the most immunogenic of all blood group antigens and the corresponding antigens (C, E and K) are more frequently found in blood donors of European ethnicity.

40
Q

If C and E negative blood were to be selected from a pool of donors with European ancestory, which phenotype would be best to select from?

A

The r phenotype (cde)

41
Q

If C and E negative blood were to be selected from a pool of donors with African ancestory, which phenotype would be best to select from?

A

The R0 phenotype (cDe)

42
Q

What ethnicity has the highest frequency of e negative blood?

A

Native Americans

43
Q

Individuals of Asian decent are most likely what Rh phenotype?

A

R1 (70%)

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