Regulation of RBF & ECF Flashcards
renal blood flow vasodilators (4)
ANP
glucocorticoids
NO
prostaglandins
vasoconstrictors of renal blood flow (5)
a1 sympathetic stimulation Angiotensin II ADH ATP endothelin
increasing resistance of the afferent arteriole will: (3 things)
decrease Pgc, GFR, RBF
increasing resistance of the efferent arteriole will (2 things)
increase GFR and RBF
increasing resistance of both the afferent and the efferent arteriole will (2 things)
no change GFR
decrease RBF
aldosterone release is stimulated by (2)
increased [AngII]
increased plasma [K+]
stimulates Na+ absorption in the late distal tubule and collecting duct
aldosterone
vasoconstrictor; favors salt retention, thirst, aldosterone release, and elevation of arterial BP
Angiotensin II
this hormone stimulates Na+/H+ exchange in the proximal tubule?
Angiotensin II
Angiotensin II favors (4 things)
Na+H+ exchange: salt retention
elevation of arterial BP
thirst
aldosterone release
increases GFR, decreases NaCl reabsorption by the CD
Inhibits secretion of renin & aldosterone
ANP
how does ANP increase GFR?
dilates the afferent arteriole
constricts the efferent arteriole
what chemical inhibits secretion of renin & aldosterone?
ANP
effects of ADH (3)
increased Na+K+2Cl- activity
increased urea permeability
aquaporin insertion in the CD
what stimulates ADH release (2)
increased plasma osm
decreased plasma vol
causes of reduced Osmolar clearance (3)
decreased GFR
increased aldosterone
Conn’s syndrome & diseases
causes of increased osmolar clearance (2)
diuretic use
decreased aldosterone
low ADH
high plasma Osm
decreased urine Osm
diabetes inspidus
low aldosterone
hyponatremia
increased ECF vol.
concentrated urine
SIADH
stimulates K+ movement into the cell (3)
B2 stimulation
insulin
alkalosis
stimulates K+ movement out of the cell (4)
a1 stimulation
aldosterone
exercise
acidosis
where does K+ reabsorption occur
a-intercalated cells
where does K+ secretion occur
principal cells
mechanism of K+ reabsorption
H+K+ATPase. Exchange
effects of low K+ diet
decreased K+ excretion
effects of high K+ diet (3)
increased K+ secretion
increased Na+K+ATPase
increased aldosterone
aldosterone’s effects on K+
secretion by Na+K+ATPase
modulators of Ca2+ reabsorption (2)
PTH
cAMP
sites of isosmotic water absorption in the nephron (2)
early proximal tubule
late proximal tubule
dilution segments of nephron (2)
thick ascending limb
early distal tubule
water permeability of the late distal tubule & CD (2)
impermeable w/o ADH
permeable to H2O w/ ADH
aldosterone’s effects on the collecting duct (3)
increases # of:
- Na+ channels
- Na+K+ATPase pumps
- K+ channels
where is carbonic anhydrase activity (2)
early proximal tubule
a-intercalated cells
