Regulation of Metabolism Flashcards
1
Q
What are the roles of the 7 major metabolic pathways?
A
Glycolysis glucose>>>pyruvate Gluconeogenesis pyruvate/lactate>>>>>glucose Glycogen metabolism glucose storage Fatty acid metabolism stored as TAG Citric Acid Cycle - NADH Oxidative phosphorylation - ATP Amino acid metabolism
2
Q
What regulates the major metabolic pathways?
A
- compartmentation inside cell
- reciprocal regulation of metabolic pathway enzymes
* allosteric regulation of enzymes (modulated)
* covalent modification (de/phosphorylation) on/off - organ specialization
- hormonal regulation (epinephrine, glucogon, insulin, cortisol)
3
Q
Which metabolites connect the metabolic pathways?
A
G6P
Pyruvate
Acetyl CoA
4
Q
What is the role of epinephrine in regulating the metabolic pathways?
A
increase glycogen breakdown- increase prod. of glucose
decrease glycogen synthesis - increase prod. of glucose
increase gluconeogenesis - increase prod. of glucose
increase glycolysis - increased ATP in muscle
increase FA mobilization
5
Q
What is the role of glucagon in regulating the metabolic pathways?
A
increase glycogen breakdown decrease glycogen synthesis decrease glycolysis increase gluconeogenesis increase FA metabolism
6
Q
What is the role of insulin in regulating the metabolic pathways?
A
increase glucose uptake increase glycogen synthesis decrease glycogen breakdown increase glycolysis, Acteyl Co production increase FA synthesis increase TAG synthesis
7
Q
What is the role of cortisol in regulating the matabolic pathways?
A
increase gluconeogenesis
stimulate FA mobilization
