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CMBM 4 > Anitfungal Agents > Flashcards

Anitfungal Agents Flashcards

1
Q

This pathogenic fungus invades keratinized structures and is the cause of tinea pedis, tinea corporis, or tinea unguium.

A

dermatophytes

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2
Q

What is the cause of Pityriasis versicolor?

A

Malassezia furfur

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3
Q

What is the cause of sportrichosis?

A

Sporothrix schenckii

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4
Q

What endemic mycoses causes summer flu and clinical symptoms that resemble TB pneumonia?

A

Histoplasma capsulatum

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5
Q

What endemic mycoses causes fever, night sweats, weight loss and/or pulmonary symptoms?

A

Blastomyces dermatitidis

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6
Q

What produces fever, productive cough, chest pain and extreme fatigue?

A

coccidiodes immitis

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7
Q

What produces destruction of facial features? (captain’s wheel)

A

Paracoccidiodes neoformans

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8
Q

What causes vulvovaginitis, oral thrush and esophageal candidiasis?

A

Candida albicans

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9
Q

What fungus could cause meningioencephalitis?

A

Cryptococcus neoformans

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10
Q

What fungus could initially present as a sinus infection?

A

Aspergillus fumigates

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11
Q

What causes headaches and orbital cellulitis?

A

Mucor rhizopus

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12
Q

What would produce headache, non-productive cough, respiratory failure and/or cyanosis?

A

Pneumocysts jiroveci

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13
Q

How would you treat dermatophytes?

A

Topical: Miconazole, Clotrimazole

Oral: Griseofulvin, Ketoconazole, (Itraconazole)

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14
Q

How would you treat Sporothrix schenckii?

A

Itraconazole

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15
Q

How would you treat Histoplasma capsulatum?

A

Itraconazole
Ketoconazole
Amphotericin B

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16
Q

How would you treat Blastomyces dermatitidis?

A

Itraconazole
Ketoconazole
Amphotericin B

17
Q

How would you treat Coccidiodes immitis?

A

Amphotericine B + Flucytosine
Later Fluconazole
(ketoconazole, Itraconazole)

18
Q

How would you treat Candida albincans?

A

Nystatin (cutaneous)
Fluconazole
Itraconazole
Clotrimazole (topical and Vaginal suppositories)

19
Q

How would you treat Aspergillus?

A

Amphotericin B
Voriconazole (for invasive)
Caspofungin (for Amp B resistant Aspergillus)

20
Q

How would you treat Cryptococcus neoformans?

A

Amphotericin B + flucytosine initially

followed by fluconazole

21
Q

How would you treat Mucor/Rhizopus?

A

Ampthotericin B

22
Q

How would you treat Pneumocystis jiroveci?

A

TMP/SMX

23
Q

What are the major classes of antifungal drugs?

A 
Polyenes
Allylamines
Azoles
Echinocandins
Pyrimidine inhibitor
24
Q

What is the mechanism of action of Polyenes and give examples?

A

bind to ergosterol and disrupt cell membrane

Amphotericin B
Nystatin

25
Q

What is the mechanism of action of Allylamines and give an example?

A

block ergosterol synthesis in cell membrane

Terbinafine

26
Q

What is the mechanism of action of Azoles and give examples?

A

block ergosterol synthesis in cell membrane

Ketoconazole
Itraconazole
Fluconazole
Voriconazole
Clotrimazole
27
Q

What is the mechanism of action of Echinocandins and give an example?

A

inhibit glucon synthase causing cell wall synthesis inhibition

28
Q

What is the mechanism of action of Pyrimidine inhibitors and give an example?

A

Flucytosine

CMBM 4 (3 decks)

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