Regulation of Gut Function and Motility Flashcards
Where do the sympathetic preganglionic neurons arise from
Where do the postganglionic neurons arise from
Where does the parasympathetic nervous system arise from
What is the enteric nervous system
Intrinsic
Autnomous
Also interact with sympathetic and parasympathetic
Where are the meissner and auerbach plexus located
What does the myentric plexus do
What does the submucosal plexus do
What is the local reflex of the enteric nervous system
What does the extrinsic nervous system do on intrisic
What is hirschsprung disease
Common cause of neonatal bowel obstruction
Tonal contraction without relaxation
Intestinal distension proximal to rectum
Most require surgery
Congenital absence of ganglion of myenteric and submucosal
What are examples of endocrine gut hormones
What are examples of paracrine gut hormones
What are example of neurocrine cells
What are enteroendocrine cells
Possess hormone containg granules concetrated at basolateral membrane
Secretion in response to stimuli: small peptides, amino acids, fatty aicds, oral glucose, distension of an organ and vagal stimulation
What is gastrin
Synthesis in gastric antrum and upper small itestine
Stimulated by amino acids and peptides in stomach, gastric distension, vagus nerve
Stimualtes gastric acid secretion by parietal cells
Release inhibited when ph <3
Tophic effects on mucosa of the small intestine, colon and stomach
Secretin
Cholecystokinin
Glucose-dependent insulinotropic peptide
What is motilin
inCREASE GASTROINTESTINAL
What is somatostatin
What is glucagon like peptide-1
What is pancreatic polypeptide
What is peptide YY
Secreted from cells found through mucosa of ileum, colon and rectum
Released from L cells
Reduces intestinal motility, gallbladder contraction and pancreatice exocrine secretion
What does vasoactive intestinal epptide do
What does gastrin releasing peptide do
What do enkephalins do
Increase smooth muscle tone do inhibit perastalsis
Binds to oiod receptor
What is Zollinger Ellison syndrome
What is the cephalic phase
What is the gastric phase
What is the intestinal phase
Food reaches duodenum
Lipids and pH stimulate stretch and chemoreceptors
Inhibit the parasymp, inhibit gastric secretions
Secretion Gip and cholecystokinin released by duodenum, inhibit gastric secretion
