Regulation of Gut Function and Motility Flashcards

1
Q

Where do the sympathetic preganglionic neurons arise from

A
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2
Q

Where do the postganglionic neurons arise from

A
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3
Q

Where does the parasympathetic nervous system arise from

A
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4
Q

What is the enteric nervous system

A

Intrinsic

Autnomous

Also interact with sympathetic and parasympathetic

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5
Q

Where are the meissner and auerbach plexus located

A
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6
Q

What does the myentric plexus do

A
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7
Q

What does the submucosal plexus do

A
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8
Q

What is the local reflex of the enteric nervous system

A
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9
Q

What does the extrinsic nervous system do on intrisic

A
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10
Q

What is hirschsprung disease

A

Common cause of neonatal bowel obstruction

Tonal contraction without relaxation

Intestinal distension proximal to rectum

Most require surgery

Congenital absence of ganglion of myenteric and submucosal

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11
Q

What are examples of endocrine gut hormones

A
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12
Q

What are examples of paracrine gut hormones

A
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13
Q

What are example of neurocrine cells

A
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14
Q

What are enteroendocrine cells

A

Possess hormone containg granules concetrated at basolateral membrane

Secretion in response to stimuli: small peptides, amino acids, fatty aicds, oral glucose, distension of an organ and vagal stimulation

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15
Q
A
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16
Q

What is gastrin

A

Synthesis in gastric antrum and upper small itestine

Stimulated by amino acids and peptides in stomach, gastric distension, vagus nerve

Stimualtes gastric acid secretion by parietal cells

Release inhibited when ph <3

Tophic effects on mucosa of the small intestine, colon and stomach

17
Q

Secretin

A
18
Q

Cholecystokinin

A
19
Q

Glucose-dependent insulinotropic peptide

A
20
Q

What is motilin

A

inCREASE GASTROINTESTINAL

21
Q

What is somatostatin

A
22
Q

What is glucagon like peptide-1

A
23
Q

What is pancreatic polypeptide

A
24
Q

What is peptide YY

A

Secreted from cells found through mucosa of ileum, colon and rectum

Released from L cells

Reduces intestinal motility, gallbladder contraction and pancreatice exocrine secretion

25
Q

What does vasoactive intestinal epptide do

A
26
Q

What does gastrin releasing peptide do

A
27
Q

What do enkephalins do

A

Increase smooth muscle tone do inhibit perastalsis

Binds to oiod receptor

28
Q

What is Zollinger Ellison syndrome

A
29
Q

What is the cephalic phase

A
30
Q

What is the gastric phase

A
31
Q

What is the intestinal phase

A

Food reaches duodenum

Lipids and pH stimulate stretch and chemoreceptors

Inhibit the parasymp, inhibit gastric secretions

Secretion Gip and cholecystokinin released by duodenum, inhibit gastric secretion