Regulation of Gluconeogenesis

Question 1

What will promote gluconeogenesis and inhibit glycolysis?

Answer 1

FA oxidation

Question 2

What are the 3 ways that FA oxidation promotes gluconeogenesis and inhibits glycolysis?

Answer 2

FA oxidation causes an INCREASE in ACETYL-CoA in mito, which:

1) + PYRUVATE CARBOXYLASE
2) + CITRATE (which is a NEGATIVE effector of PFK-1).
a) This results in a decrease in F 1,6-biP, that - PYRUVATE KINASE

FA oxidation causes an INCREASE in ATP,
3) -AMP (favors gluconeogenesis)