Regulation of gene expression by non-coding RNAs

Question 1

What are the three classes of small RNA molecules?

Answer 1

miRNA, siRNA and piRNAs

Question 2

Who is transporting the interfering RNA?

Answer 2

Argonaute or Piwi protein

Question 3

What are Epi-drugs?

Answer 3

They block gene expression by epigenetic markers or block/activate enzyme activity, non-chromatin targets

Question 4

Who slices the miRNA and with what mechanism?

Answer 4

Argonaute proteins, Mg

Question 5

What are the roles of noncoding RNA?

Answer 5

Scaffolds bringing together more proteins, localize proteins to specific sequneces; cis-induce control of genes; trans-acts on different chromosome

Question 6

For what is chaperone remodelling used for?

Answer 6

histone exchange, histone octamer removal, histone octamer exchange

Question 7

What is the “unique” histone linker involved in nucleosome-outgoing DNA?

Answer 7

H1

Question 8

What is CENP-A?

Answer 8

Histone variant of H3

Question 9

What is the function of CENP-A?

Answer 9

Binds to kinetochore