Morphogenesis Flashcards
What is morphogenesis stimulated by?
Chemical factors-contc. extracellular matrix and mechanical factors- contact with other cells
What are the extra cellular, environmental cues that guide migrant cells?
Specific cell-surface receptor proteins (repelling or inviting)
What are some intracellular cues?
inside the proteins are connected to actin and myosin cytoskeleton moving the cell along
What are two important examples of guiding influence?
neurons in developing brain and cancer sells when they metastasize
What is CXCR4?
A G-protein coupled receptor that influences chemotaxis and is dependent on an extracellular ligant
What is CXCL12
Extracellular ligant that induces directional cell migration
What happens with no CXCL?
Random blebbing
What are the most important migrant cells
Those from neural crest
What forms the neural tube?
Neural ectoderm
What is the survival factor that is involved with neural crest cell migration?
Endothelin-3
How can you detect Endothelin-3 mutation?
Undeveloped colon
What is Kit?
Receptor tyrosine kinase, survival factor
Where is Endothelin-3 produces?
in tissues along migration pathway
Where is Kit produced?
Cell surface of migrant cells
What is the ligant for Kit?
Steel factor
What happens with mutation in Kit?
Defect pigmentation
What are cadherins?
cell-adhesion molecules, ca dependent
What do different types of cadherins lead to?
Sorting out cells
Apart from cell adhesion what is important in cell separation?
Active cell repelling
What is convergent extension?
Active rearrangement by migrating cells
What is planer polarity?
All cells pointing in a specific direction
give an example of planer polarity defect
mutation in Flamingo gene that makes mice deaf because of different direction of hairs in inner ear
From where did lung tissue originate?
Epithelial buds, foregut
What needs to happen for formation of bronchial tree?
Invasion of mesenchyme
