Regenerative models Flashcards
1
Q
genetic screen
A
introduction of random mutations and screening for phenotypic/other observable differences
2
Q
example of genetic technologies that have made studying the genetic basis of traits easier
A
quick/cheap genome sequencing
transcriptomics
RNAi
single cell approaches, RNAseq, ChIP-seq tech etc etc
3
Q
examples of regenerative models
A
hydra, planarians, acoel worms (Hofstenia miamia)
4
Q
tools used for mapping hydra cells
A
drop-seq- got transcriptomes from 25k cells, clustered them- found clustering with developmental stage and trajectory, allowed tracking of development kinda- useful for studying regeneration
can build ‘paths’ of differentiation computationally
5
Q
metagene
A
genes expressed together (coregulation)- get clustered together
6
Q
A
