Regeneration & Repair Flashcards
Resolution
Initiating Factor removed
Tissue undamaged or able to regenerate
Repair
Initiating factor is still present
Tissue damaged and unable to regenerate
Does lobar pneumonia undergo resolution or repair?
Resolution
Bacteria is removed (so initiating factor removed)
Pneumocytes regenerated
Does liver serosis undergo resolution or repair?
Repair
Alcohol still present (initiating factor is still present)
Causes fibrosis, not resolved not repair is still happening
COVID fibrosis
Fibrotic tissue due to excess inflammation
Healing by 1st Intention
Surgical Cut
-Fibrin Join (weak)
- Then collagen join forms (strong)
Smaller Scar
Healing by 2nd Intention
Skin Wound
- Cells grow in when fibrin cannot
- Capillaries and fibroblasts grow in
- Endothelial Cells grow in
Bigger Scar
Which tissue replaces damaged tissue in Repair?
Fibrous Tissue
Collagen is produced by Fibroblasts
- Fibrosis Occurs
Which organs cannot undergo resolution and therefore undergo repair?
Heart after a Myocardial Infarction –> Myocardial Fibrosis
Brain after a Cerebral Infarction –> Fibrosis in the brain (Gliosis)
Spinal Cord after trauma
Cells that regenerate
Hepatocytes
Pneumocytes
All blood cells
Gut epithelium
Skin epithelium (1st and 2nd intention)
Osteocytes
Cells that don’t regenerate
Myocardial cells
Neuons
Is repair or resolution occurring?
1 overdose of paracetamol
Resolution:
Not a constant overdose so initiating factor is removed
Liver resolution
Is repair or resolution occurring?
Broken bone (kept stable in a sling)
Resolution
Initiating factor removed as it is kept stable
Is repair or resolution occurring?
Broken bone (moving arm not in a sling)
Repair
Non-stable fracture, issue still present so cannot resolve
