Regeneration in the mature NS

Question 1

Wallerian degeneration

Answer 1

The part of an axon separated from the cell body in an injury degenerates distal to the injury. antereograde or orthograde degradation.

Question 2

define muscle atrophy

Answer 2

muscle wasting

Question 3

effectes of denervated muscle

Answer 3

muscle atrophy (external electrical input can decrease it), achR reversal to embryonic, MuSK increase,

Question 4

What is MuSK?

Answer 4

is a receptor tyrosine kinase needed for neuromuscular junction formation.

Question 5

what growth factor promotes xenopus tail regrowth?

Answer 5

BMP bone morphogenic protein

Question 6

NoGo A where and weight

Answer 6

in oligos and developing neuron 200kd

Question 7

NoGo B where and weight

Answer 7

in many cells 55kd

Question 8

NoGo C where and weight

Answer 8

muscle 25kd

Question 9

Repair of spinal cord options and key points

Answer 9

transplant fetal cells, olfactory sheath cells (in trails now quite successful), neuronal precursors in adult brain.

Question 10

regeneration on PNS

Answer 10

cell death more likely closer to the soma. crush better than cut basal lamina and extra cellular matrix still intact

Question 11

Repair tried in which two diseases

Answer 11

Huntingtons and parkinson

Question 12

Might not be nogo might be astrocytes

Answer 12

no correlation between NoGo amount and ability to recover.