Regeneration and repair Flashcards
What happens in resolution?
- Initiating factor removed
- The tissue is undamaged or able to regenerate
What is repair?
- Initiating factor still present
- Tissue damaged and unable to regenerate
What can you say about the liver here?
The liver can regenerate
Can remove half of the liver and the rest can regenerate
What is lobar pneumonia?
This affects only one lobe
Caused by bacteria
In a CT scan when you see white blobs in the lungs what is this a sign of?
Fibrosis
In skin wounds, what is healing by 1st intention?
This is when you make a cut through the skin, bring edges of the skin together and then suture or staple it
In skin wounds what is healing by 2nd intention?
Cant get edges of wounds together to suture it - could be due to too much trauma
You then have to excise skin tumour
What is repair
replacement of damaged tissue by fibrous tissue
collagen produced by fibroblasts
examples
–heart after myocardial infarction
–brain after cerebral infarction
–spinal cord after trauma
-Tissue damage in area where tissue cannot regenerate such as the Heart
Cells that can regenerate
hepatocytes
pneumocytes
all blood cells
gut epithelium
skin epithelium
osteocytes
Cells that cant regenerate?
myocardial cells
neurones
Man aged 30 takes a large overdose paracetamol overdose and doesn’t come to hospital for 2 days. He spends a few days on ITU with liver failure but then recovers.
What will be happening in his liver - resolution or repair?
Resolution
A child aged 3 falls off a climbing frame onto his hand, he fractures his clavicle. He has his arm in a sling for 4 weeks and is very good about keeping it in the sling
What will be happening in his clavicle - resolution or repair?
Resolution
