Red Cell Metabolism Flashcards
what are the biochemical pathways in red cell metabolism?
anaerobic EMP pathway
Rapoport Leubering shunt
pentose phosphate pathway
what does the EMP pathway supply
energy
pk converts pyruvate to lactate to produce ATP
what is the rapoport leubering shunt?
a shunt of emp pathway that produces 2-3 DPG (which increases oxygen affinity
what is the pentose phosphate pathway?
G6PG converts glucose 6 phosphate to 6 phosphogluconate to produce glutathione and NADPH.
what are the proteins that maintain Hb biconcave shape?
spectrin, ankyrin, protein 4.1, actnie, band 3 band 4.2
what are the principle glycoproteins in RBC
band 3, GPA, GPC, RhAG
What are the functions of glycoproteins?
recognition, transport and anchorage
what provides skeletal support to RBC?
alpha and beta spectrin proteins
what is hereditary spherocytosis?
affects protein interactions between skeleton membrane and lipid bilayer due to mutated spectrin and ankyrin
what are the transport proteins?
band 3, aquaporin, glut-1, kidd, rhD
what does Kidd transport?
urea
what does band 3 transport?
anions and facilitates gas exchange
what does glut-1 transport?
glucose and L-dehydroascorbic acid
