recombinant cytokines and clinical uses, therapeutic Abs

Question 1

Renal cell carcinoma, metastatic melanoma

Answer 1

Aldesleukin (IL-2)

Question 2

anemias (especially in renal failure)

Answer 2

epoetin alfa

Question 3

recovery of bone marrow

Answer 3

IL-3
filgrastim (granulocyte colony-stimulating factor)
or
sargramostim (granulocyte-macrophage colony stimulating factor)

Question 4

hepatitis B and C, Kaposi’s sarcoma, leukemias, malignant melanoma

Answer 4

alpha-interferon

Question 5

multiple sclerosis

Answer 5

Beta-interferon

Question 6

chronic granulomatous disease

Answer 6

y-interferon

Question 7

thrombocytopenia

Answer 7

oprelvekin (IL-11)
or
thrombopoietin

Question 8

name agent and target for prevent acute transplant rejection

Answer 8

Muromonab-CD3 (OKT3) => CD#

Question 9

name agent and target for antidote for digoxin intoxication

Answer 9

Digoxin immune Fab => digoxin

Question 10

name agent and target for Crohn’s disease, rheumatoid arthritis, psoriatic arthritis, anklyosing spondylitis

Answer 10

infliximab=> TNF-alpha
or
etanercept=>TNF-alpha

Question 11

name agent and target for Crohn’s disease, rheumatoid arthritis, psoriatic arthritis

Answer 11

adalimumab => TNF-alpha

Question 12

name agent and target for preventing cardiac ischemia in unstable angina and patients w/ percutaneous coronary intervention

Answer 12

abciximab => glycoprotein IIb/IIIa

Question 13

name agent and target for HER2-overexpressing breast cancer

Answer 13

trastuzumab (herceptin) => HER2

Question 14

name agent and target for B-cell non-Hodgkin’s lymphoma

Answer 14

rituximab => CD20

Question 15

name agent and target for additional line of treatment for severe asthma

Answer 15

Omalizumab => IgE