Autoantibodies and disorder

Question 1

ANA

Answer 1

SLE, nonspecific

Question 2

anti-dsDNA, anti-Smith

Answer 2

SLE

Question 3

antihistone

Answer 3

drug-induced lupus

Question 4

rheumatoid factor, anti-CCP

Answer 4

rheumatoid arthritis

Question 5

anticentromere

Answer 5

Scleroderma (CREST syndrome)

Question 6

anti-Scl-70 (anti-DNA topoisomerase I)

Answer 6

Scleroderma (diffuse)

Question 7

antimitochondrial

Answer 7

primary biliary cirrhosis

Question 8

IgA antiendomysial, IgA anti-tissue transglutaminase

Answer 8

Celiac disease

Question 9

anti-basement membrane

Answer 9

Goodpasture’s syndrome

Question 10

anti-desmoglein

Answer 10

pemphigus vulgaris

Question 11

antimicrosomal, antithyroglobulin

Answer 11

Hashimoto’s thyroiditis

Question 12

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 12

polymyositis, dermatomyositis

Question 13

anti-SSA (anti-Ro)

Answer 13

Sjogren’s syndrome

Question 14

anti-SSB (anti-La)

Answer 14

Sjogren’s syndrome

Question 15

Anti-U1 RNP (ribonucleoprotein)

Answer 15

mixed connective tissue disease

Question 16

anti-smooth muscle

Answer 16

autoimmune hepatitis

Question 17

anti-glutamate decarboxylase

Answer 17

diabetes mellitus type I

Question 18

c-ANCA (PR3-ANCA)

Answer 18

granulomatosis w/ polyangiitis (Wegener’s)

Question 19

p-ANCA (MPO-ANCA)

Answer 19

Microscopic polyangiitis, Churg-Strauss syndrome, Primary sclerosing cholangitis

Question 20

anti-TSH

Answer 20

Graves

Question 21

anti-ACh receptor

Answer 21

Myasthenia gravis