Recognition Of Microbial Products Through TLR

Question 1

R:
TLR2:TLR6 heterodimer

L
MR
CCR
CLR

Answer 1

Lipoteichoic acid/zymosan

Bacteria and fungi

Monocytes, macrophages, DCs, eosinophils, basophils, mast cells

Plasma membrane

Question 2

R:
TLR3

L
MR
CCR
CLR

Answer 2

DS viral RNA

Viruses

NK cells, macrophages

Endoscopes

Question 3

R:
TLR4:TLR4 homodimer

L
MR
CCR
CLR

Answer 3

lipopolysaccharide

Gram-negative bacteria

Macrophages, DCs, mast cells, eosinophils

Plasma membrane

Question 4

R:
TLR5

L
MR
CCR
CLR

Answer 4

Flagellin

Bacteria

Intestinal epithelium, macrophages

Plasma membrane

Question 5

R:
TLR7

L
MR
CCR
CLR

Answer 5

SS viral RNAs

Viruses

Plasmacytoid DCs, macrophages, NK cells, eosinophils, B cells

Endosomes

Question 6

R:
TLR8

L
MR
CCR
CLR

Answer 6

SS viral RNAs

Viruses

NK cells

Endosomes

Question 7

R:
TLR9

L
MR
CCR
CLR

Answer 7

Unmethylated CpG-rich DNA

Bacteria/viruses

Plasmacytoid DCs, B cells, eosinophils, basophils

Endosomes

Question 8

R:
TLR 10 homodimer and her toddlers with TLR1 and 2

L
MR
CCR
CLR

Answer 8

Unk

Unk

Plasmacytoid DCs, basophils, eosinophils, B cells, macrophages

Unk

Question 9

Receptor:
TLR1:TLR2 heterodimer

Ligands (L)
Micro organisms recognized (MOR)
Cells carrying receptor (CCR)
Cellular location of receptor (CLR)

Answer 9

Lipopeptides/GPI

Bacteria

Monocytes, macrophage, DC, eosinophils, basophils, mast cells

Plasma membrane