receptors & terminology for describing effects of drug Flashcards
1
Q
what is the definition of a receptor?
A
protein or protein complex
- usually in cell membrane
- detector of cell signals
2
Q
what are the “3 S’s” of receptor characteristics?
A
1) sensitive
2) selective
3) specific in its response
3
Q
what are the 3 possible direct responses that occur when a receptor is bound by an agonist?
A
1) enzyme activation
2) activation of transport system
3) opening of ion channel
4
Q
intracellular receptors alter _____ expression
A
DNA
5
Q
what is “tachyphylaxis”?
A
very rapid desensitization
6
Q
the max therapeutic effect of a drug is known as its _______
A
efficacy
7
Q
the effect of a drug relative to its dose is called its _______
A
potency
8
Q
what is the therapeutic index a measure of?
A
measure of the clinical safety of a drug
9
Q
what ratio gives us the therapeutic index?
A
(TD50)/(ED50)
toxic dose divided by the effective dose
