Receptors & Effects Handout

Question 1

Effects of stimulating this receptor type results in:

• Vasoconstriction of BVs, ureter, arrector pili muscles, bronchioles, seminal tract, and increases saliva production, insulin resistance
• Neuronal effects: appetite suppression and causes NE to decreased glutamergic postsynaptic potentials
• Increases NE
• Excessive stimulation causes orthostatic hypotension

Answer 1

a1 receptors

Question 2

Phenylephrine:
Receptor subtype?
Agonist or antagonist?

Answer 2

a1 agonist

Question 3

HTN meds, Quetiapine, Risperidone:
Sympathetic receptor subtype target?
Agonist or antagonist?

Answer 3

a1 antagonist

Question 4

Name the receptor subtype:

• Located in prefrontal cortex
• located on both presynaptic and postsynaptic cells
• Decreases release of Ach and NE
• Increases epinephrine

Answer 4

a2 receptors

Question 5

Clonidine, guanfacine, concerta, adderal XR:
Name the sympathetic receptor subtype
Agonist or antagonist?

Answer 5

a2 agonist

Question 6

Aripiprazole, clozapine, lurasidone, mirtazapine, olanzapine, paliperidone, risperidone, quetiapine, and ziprasidone:
What sympathetic receptor subtype?
Agonist or antagonist?

Answer 6

a2 antagonists

Question 7

Name the sympathetic receptor subtype:

-Increases HR, cardiac muscle contractility, lipolysis

Answer 7

B1 receptors

Question 8

Dobutamine acts on what receptor subtype?

Agonist or antagonist?

Answer 8

B1 agonist

Question 9

Name the sympathetic receptor subtype:

• Heart muscle contraction
• Bronchiole dilation
• Glycogenolysis
• Inhibit histamine release from mast cells

Answer 9

B2 receptors

Question 10

Salbutamol, Formoterol, and terbutaline act on what sympathetic receptor subtype?
Agonist or antagonist?

Answer 10

B2 agonists

Question 11

Salivation, lacrimation, urination, defecation, GI pain, emesis are d/t agonist effects on what receptor type?

Answer 11

Muscarinic

Question 12

Pilocarpine acts on what receptor type?

Agonist or antagonist?

Answer 12

M agonist

Question 13

Scopolamine, atropine, and diphenhydramine act on what receptor type?
Agonist or antagonist?

Answer 13

M antagonists

Question 14

Succinylcholine, atracurium, and tubocurarine act on what receptor type?
Agonist or antagonist?

Answer 14

Nicotinic antagonist

Question 15

Name the receptor type:

• Stimulation causes weight gain
• Receptors found in tuberomammillary nucleus of hypothalamus
• Receptors found in cortex and neural excitement causes neuronal excitation or wakefulness

Answer 15

H1