Antipsychotic Drugs

Question 1

Name the 3 high potency antipsychotics

Answer 1

Trifluoperazine, Fluphenazine, Haloperidol

Try to Fly High

Question 2

Name the low potency antipsychotics

Answer 2

Chlorpromazine and Thioridazine

Cheating Thieves are Low

Question 3

Adverse effects of high potency antipsychotics?

Answer 3

EPS: ADAPT
Hours to days: Acute Dystonia (muscle spasm, stiffness, oculogyric crisis)
Days to mos: Akathisia (restlessness), Parkinsonism (bradykinesia)
Mos to yrs: Tardive dyskinesia (orofacial chorea)

Question 4

Adverse effects of low potency antipsychotics?

Answer 4

Anticholinergic: dry mouth, constipation, blurry vision
Antihistamine: sedation
a1 blockade: orthostatic hypotension

Chlorpromazine and Thioridazine

Question 5

Use for Clozapine?

Answer 5

Tx-resistant schizophrenia or schizoaffective disorder and suicidality in schizophrenia

Question 6

Adverse effects of all 2nd gen antipsychotics?

Answer 6

All prolong QT

Decreased EPS and anticholinergic SEs than typical 1st gen

Question 7

Which 2nd gen antipsychotics can cause metabolic sx such as weight gain, diabetes and hyperlipidemia?

Answer 7

“Pines”

Olanzapine and Clozapine

Question 8

What should you monitor in someone taking clozapine?

Answer 8

WBC count –> agranulocytosis and dose-related seizures

Question 9

Which 2nd gen antipsychotic associated with hyperprolactinemia (amenorrhea, galactorrhea, gynecomastia)

Answer 9

Risperidone