Receptors and Signalling Flashcards
What are the principles of Receptor Signalling?
Receptors mediate the actions of pharmacological agonists and antagonists.
Receptors determine the quantitative relationship between dose or concentration of the drug and the pharmacological effects.
Receptors can cause signal amplification and thus receptors can induce a biological response at very low concentrations of ligand/drug
What are Cell Surface Receptors?
Act as signal transducers (converts an extracellular signal into an intracellular response. Intracellular signaling proteins trasmit message from the receptor to target proteins, alteration in activity/function of these target proteins leads to a cellular/physiological response)
What are G-protein Coupled Receptors?
metabotropic, ligand binding to receptor activates a G-protein which then activates or inhibits an enzyme or an ion channel
What is the Structure of G-Protein Coupled Receptors?
What is a GsPCR?
What is a GiPCR?
What is a GqPCR?
What is a G12/13PCR?
What is GPCR signalling?
What are Heterotrimeric G-proteins?
What are Ligand Gated Ion Channels?
Transmembrane proteins that open to allow ions to pass through the membrane in response to the binding of a ligand to receptor. Common ligands include neurotransmitters. Involved in the rapid transmission of a signal (ms).
Important for communication between neurons and other cells. Occur at synapses, receptors are located at post-synaptic cell, neurotransmitters released from presynaptic cell
What is the Structure of Ligand Gated Ion Channels?
What is the Classification of Ligand Gated Ion Channels?
What are Nicotinic Acetylcholine Receptors?
What are Ionotropic Glutamate Receptors?
