Metabolism and Pharmacokinetics - WIP

Question 1

What are some factors that affect Metabolism?

Answer 1

Age, genetic polymorphisms, route of administration, physiochemical properties of the drug

Question 2

What are the phases of biotransformation?

Answer 2

Phase I - functionalisation, increase the reactivity with the addition of low-molecular-weight functional groups to expose or introduce a polar group

Phase II - conjugation, increase solubility with conjugation with a higher-molecular-weight water soluble group

Question 3

What is the role of CYP450 in metabolism?

Question 4

Explain Oxidation reactions in Phase I Biotransformation

Question 5

Explain Reduction reactions in Phase I Biotransformation

Question 6

Explain Hydrolysis reactions in Phase I Biotransformation

Question 7

Explain Conjugation reactions in Phase II Biotransformation

Question 8

What is Xenobiotic Biotransformation?

Question 10

What are the Orders of Elimination?

Question 11

What are the Parameters of Pharmacokinetics?

Question 12

What is the equation for Exponential Decay?

Answer 12

C = C0 e-Kelt

Where C is the concentration after time t