Receptors and Other Drug Targets

Question 1

Receptors

Answer 1

• MAJOR DRUG TARGETS

- endogenous molecular targets for hormones, neurotransmitters, growth factors, cytokines, other mediators

Question 2

Agonists

Answer 2

ACTIVATE receptors

Question 3

Antagonists

Answer 3

BLOCK or INHIBIT receptors

Question 4

Ligand

Answer 4

• generic ter, for all agents that bing to a receptor

- agonist, antagonist, endogenous agents, synthetic drugs, etc.

Question 5

Each receptor generally bings and responds to only one endogenous cellular ligand.

Answer 5

TRUE (specificity/selectivity of action)

Question 6

Different cells and tissues express different sets of receptors.

Answer 6

TRUE (specificity/selectivity)

Question 7

Enzymes

Answer 7

• other important drug target
• target human enzymes
• target bacterial, viral, and microbial enzymes

Question 8

Enzyme-targeted drugs are usually enzyme ___.

Answer 8

inhibitors

Question 9

Aspirin is a _____ that _____ cycle-oxygenase enzymes that make prostaglandins.

Answer 9

HUMAN (patient) enzyme; INHIBITS

Question 10

Antiviral drugs inhibit ______, which is an enzyme only present in viruses.

Answer 10

reverse transcriptase

Question 11

Ion channels and transporters

Answer 11

• other drug targets

- usually channel blockers or transport inhibitors

Question 12

Many diuretics _____ ion channels and transporters in the kidney tubules.

Answer 12

inhibit

Question 13

SSRIs stands for ____.

Answer 13

Selective serotonin re-uptake inhibitors

Question 14

What is an SSRI?

Answer 14

anti-depressants that block serotonin re-uptake transporters

Question 15

Additional drug targets include _____.

Answer 15

• anti-cancer drugs bind directly to DNA
• monoclonal antibody drugs bind diverse protein targets
  various other targets