Receptor Binding Properties

Question 1

Ligands ____ to receptors to form a ligand-receptor complex.

Answer 1

bind

Question 2

Binding is not reversible.

Answer 2

FALSE, binding IS reversible

Question 3

Binding is also known as ______.

Answer 3

Association

Question 4

Ligands bind, but are also free to ______, or come off the receptor.

Answer 4

dissociate.

Question 5

Ligand and receptor “dissociate” to become free receptor and free ligand. Because of this, the ligand-receptor complex can be defined as _____.

Answer 5

transient.

Question 6

Binding exhibits ______. The number of receptors on a cell or tissue is finite.

Answer 6

saturation.

Question 7

When there is sufficient ligand to occupy all of the receptors, adding more ligand cannot induce any additional response. This is known as _____.

Answer 7

saturation of the receptors with ligand.

Question 8

Specificity:

Answer 8

• binding to receptors exhibits remarkable specificity
• this provides great specificity to hormone, neurotransmitter, and DRUG action
• wife vs. wife sister

Question 9

Binding to receptors exhibits specificity, however there is never 100% absolute specificity.

Answer 9

TRUE

Question 10

Although something may not have 100% specificity, it will be highly _____.

Answer 10

Selective.

Question 11

Dopamine vs. norepinephrine

Answer 11

differ by 1 oxygen

Question 12

Vasopressin vs. oxytocin

Answer 12

differ by 2 of 9 amino acids

Question 13

Testosterone and estradiol

Answer 13

differ by one -CH3 group