Receptors Flashcards
0
Q
Acetylcholine effects
A
Decreased HR and CO Decreased BP Increased salivary and intestinal secretion Increased tone of detrusor (urination) Pupil constriction
1
Q
Endogenous choline receptors
A
ACh
Synthetic esters of choline (carbachol, bethanechol)
Naturally occurring alkaloids (nicotine, pilocarpine)
2
Q
Mechanism of vasodilation (Acetylcholine)
A
ACh activates M3 receptors on endothelial cells in smooth muscle of blood vessels, produces NO which diffuses to vascular smooth muscle cells, stimulates kinase G production, hyperpolarization and muscle relaxation via phosphodiesterase-3 inhibition
3
Q
Bethanechol actions
A
No nicotinic, only muscarinic
Increases intestinal activity and tone
Increases urination
