receptors Flashcards
1
Q
how do G-coupled protein receptors work?
A
ADP is bound to the alpha subunit of protein (protein has 3 parts - a b g).
The substrate binds to the extracellular receptor (on a squiggly bit - 8 membrane entries).
ADP is swapped for ATP.
Alpha subunit leaves the G protein and enters into cell.
Interacts with intracellular proteins, producing a response.
When the alpha subunit rejoins with the rest of the protein the response stops.
2
Q
example of a G-coupled protein receptor
A
adrenoreceptors
3
Q
how do ligand gated receptors work?
A
- ligand binds
- ion flow
- conformational change
- response
4
Q
how do nuclear receptors work?
A
Lipophilic substrate travels across the cell membrane.
Binds to an intracellular receptor.
Receptor travels into the nucleus.
Binds to DNA → response.
5
Q
example of what acts on nuclear receptors
A
steroids
6
Q
A
