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core drugs Flashcards

1
Q

name a beta agonist

A

salbutamol

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1
Q

name beta blockers

A

atenolol
bisoprolol
propanolol
pindolol

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2
Q

what is salbutamol used for

A

asthma

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3
Q

MOA of salbutamol

A

activates B2 adrenreceptor causing bronchodilation

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4
Q

what is atenolol used for

A

high BP, angina, post MI

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5
Q

MOA of atenolol

A

selective B1 adrenreceptor blocker
dec HR -> dec BP

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6
Q

what is bisoprolol used for

A

high BP, heart failure, angina

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7
Q

MOA of bisoprolol

A

selective B1 adrenreceptor blocker
dec HR -> dec BP

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8
Q

what is propanolol used for

A

high BP, angina, arrhythmia

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9
Q

propanolol MOA

A

non- selective B1 and B2 adrenreceptor blockers

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10
Q

what is pindolol used for

A

high BP, angina, arrhythmia

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11
Q

pindolol MOA

A

non- selective B1 and B2 adrenreceptor blockers

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12
Q

chronotropic meaning

A

heart rate

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13
Q

inotropic meaning

A

contraction force

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14
Q

name COX inhibitors

A

aspirin
ibuprofen
paracetamol

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15
Q

what is aspirin used for

A

pain relief, prevent MI or strokes

16
Q

what is ibuprofen used for

A

pain relief and inflammation relief

17
Q

what is paracetamol used for

A

pain relief and fever reduction

18
Q

aspirin MOA

A

inhibits COX 1 and COX 2
reduced production of prosglandins
reduced pain

19
Q

ibuprofen MOA

A

inhibits COX 1 and COX 2
reduced production of prosglandins
reduced pain

20
Q

paracetamol MOA

A

inhibits mostly COX 2 (in brain)

21
Q

name SERT antagonists

A

SSRIs
amitriptyline

22
Q

what are SSRIs used for

A

depression

23
Q

what is amitriptyline used for

A

depression

24
Q

SSRIs MOA

A

inhibits SERT, inc. serotonin at synapse
inc. serotonin signalling at post-synaptic cleft
alleviates symptoms of depression

25
Q

amitriptyline MOA

A

inhibits SERT and NET, inc. serotonin and NA at synapse
inc. serotonin and NA signalling at post-synaptic cleft
alleviates symptoms of depression

26
Q

name some other core drugs

A

amlodipine
thiazides
theophylline
insulin
sodium valporate
codeine

27
Q

amlodipine use

A

angina and high BP

28
Q

thiazides use

A

edema and high BP

29
Q

theophylline use

30
Q

insulin use

31
Q

sodium valproate use

A

epilepsy and bipolar

32
Q

codeine use

A

pain relief and cough supression

33
Q

amlodipine MOA

A

calcium channel blocker, dec BP

34
Q

thiazides MOA

A

blocks Na-Cl symporter, causing inc of NaCl & water secretion, dec BP

35
Q

theophylline MOA

A

inhibits phosphodiesterase, inc. in cAMP, causing bronchodilation

36
Q

insulin MOA

A

agonist at insulin receptor

37
Q

sodium valproate MOA

A

multi-targetted
- inhibits Na channels
- enhances GABAergic transmission
- inhibits T-type Ca channels

38
Q

codeine MOA

A

metabolised in the liver to form morphine
by enzyme CYP206
binds to oploid receptors

formative (3 decks)

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