Receptors Flashcards
1
Q
Gas, Gai, Gaq, Gat SPCR systems
A
2
Q
What is the GPCR signaling pathways and molecules involved?
A
- Signal binds to receptor
- Activation of receptor cause conformation change that enhances G-protein interaction
- Receptor dramatically accelerates GDP release by G-protein leading to rapid GTP binding activation
- Subunit dissociates
- G-protein regulates effector protein or By subunits regulate effector activity.
3
Q
Receptor regulation
A
4
Q
How many transmembrane sectors does GPCR have?
A
7
5
Q
What does phenylephrine target
A
GPCR alpha 1 agonist, and treats for nasal congestion
6
Q
What does cetirizine target?
A
It targets the H1 antagonist of GPCR and treats for allergy
7
Q
What does formoterol target?
A
It targets beta 2 GPCR subunit agonist , and treats for asthma
8
Q
What does propranolol target?
A
It targets beta GPCR antagonist, and treats for hypertension.
