Receptores Protes G Flashcards

1
Q

Los receptores se forman por 1 cadena que atraviesa la membrana … veces

A

7 veces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cuando llega el ligando al receptor libera

A

ADP o GDP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Subunidad de prote G donde se une el GDP:

A

G alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Gs =

A

estimula
adenilato ciclasaATP en AMPc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Gi=

A

Inhibe a adenilato ciclasa ⇢ reduce su concentración

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Gq=

A

Activa a Fosfolipasa C ⇢rompe fosfatidilinositol:

  • Diacilglicerol (membrana)
  • Inositol trifosfato (citoplasma)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

A partir de qué se sintetiza el AMPc?

A

A partir de ATP por medio de la adenilato ciclasa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

¿Qué hace AMPc?

A

Activa PKA (cinasa)
PKA migra al núcleo y activa a CREB (prote reguladora de expresion genética) ⇢CREB se une a una secuencia de ADN AMPc-CRE ⇢ se producen proteínas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

¿Qué hace el diacilglicerol?

A

Activa a PKC (dependiente de calcio) ⇢ fosforila factores de transcripción

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Muchas funciones del Ca+ son reguladas por unión con:

A

Calmodulina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CaM-quinasa función:

A
  • Activa proteínas de la expresión genética = CREB
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Gs …. canales de K+

A

cierra

How well did you know this?
1
Not at all
2
3
4
5
Perfectly