Receptor Theory

Question 1

What is a receptor

How do drugs interact with receptors

What’s a perfect drug

Answer 1

-small protein molecule on cell membranes that serve as targets for ligands

/they mimic , modify or block action of endogenous receptors

-binds to one receptor and consistently produces the desirable effect

Question 2

List types of receptors

Answer 2

1 intracellular
2 seven transmembrane receptor
3 enzyme linked transmembrane receptor
4 transmembrane ion channel

Question 3

Describe ligand gated ion channel and g-protein coupled receptor and what they do

Answer 3

• will produces or cease uptake of ions when bound to ligand to change membrane potential or ionic content within cell
• will phosphorylate proteins to produce secondary messengers

Question 4

Describe enzyme linked receptors and intracellular and what they do

Answer 4

• protein and receptor phosphorylation

- found within cell and will phosphorylation of proteins and gene expression

Question 5

Basis of naming receptors

Answer 5

1 principal endogenous agonist that activated

2 1st exogenous agonist found to activate receptor

Question 6

What is SAR in receptor theory

Answer 6

/structure activity relationship

-structure of drug corresponds to structure to receptor

Question 7

3 components needed for action by drugs

Answer 7

1 drugs reach receptor in optimal amounts to pass threshold
2 drug specific to matching receptors
3 specificity based on chemical nature of drug

Question 8

What is affinity and Intrinsic activity

Answer 8

• ability of drug to form and subsequently maintain a complex with a receptor
• ability of drug to evoke response on combing with receptor

Question 9

Types of drugs

Answer 9

1 agonist ( evoke response )
2 anatagonist ( inhibit response )

Question 10

List properties of drug action

Answer 10

1 selectivity
2 efficacy
3 potency
4 dose-response relationship

Question 11

Describe drug dose relationship

draw the graph both

Answer 11

-as drug conc increases response increases but eventually levels out at high concentrations

Question 12

Explain selectivity of drugs ( draw compare and contrast graphs )

Answer 12

-higher affinity drugs for certain receptors will aquire higher binding percentages at lower conc

Question 13

What is potency

Describe high potency and explain dangers

Answer 13

-dose required to achieve required effect of given intensity as compared to standard reference

• low conc needed to achieve specific response
• can easily poison someone at lower conc changes

Question 14

What is efficacy

Answer 14

• max response a drug can produce

- how much effect is needed