Receptor Review

Question 0

TGF-beta binds what receptors?

Answer 0

Those with ser/thr kinases leading to SMAD activation

Question 1

Ras/MAPK and Ras/PKB lead to what cell functions?

Answer 1

Cell growth and proliferation. Inhibition of apoptosis

Question 2

IFN and IL activate what pathway?

Answer 2

JAK/STAT

Question 3

Detail the erithropoitein activation pathway

Answer 3

Epo to EpoR to JAK2 to STAT5 to Tx activation

Question 4

Cushing syndrome is assoicated with what?

Answer 4

GR

Question 5

Familial early-onset hypertension

Answer 5

MR

Question 6

Breast cancer

Answer 6

ER

Question 7

AIS, Kennedy’s disease, prostate cancer

Answer 7

AR

Question 8

GRTH syndrome

Answer 8

TR

Question 9

Hypocalcemic vit-D resistant rickets

Answer 9

VDR

Question 10

Acute promyelocytic leukemia

Answer 10

RAR

Question 11

Cholera

Answer 11

Gs-alpha

Question 12

Whooping cough

Answer 12

Gi-alpha

Question 13

Familial hypertrophic cardiomyopathy

Answer 13

Ca+2

Question 14

Noonan and Costello syndromes

Answer 14

Ras

Question 15

Prostate cancer

Answer 15

SMAD

Question 16

Familial adenomatous polyposis

Answer 16

WNT

Question 17

Tamoxifen treats?

Answer 17

ER breast cancer, known as a SERM

Question 18

Retinoic acid treats?

Answer 18

AML caused by PML-RAR

Question 19

Fibrates do what?

Answer 19

Decrease high TAG levels

Question 20

TZDs to what?

Answer 20

Blood glucose reduction for Type II diabetes

Question 21

Metoprolol does what?

Answer 21

Beta blocker used for cardiac arrhythmia/angina

Question 22

Albuterol is used to treat?

Answer 22

Asthma

Question 23

GLP-1R agonist treats

Answer 23

Type 2 diabetes

Question 24

Nitroglycerin

Answer 24

Treats angina

Question 25

Epo administration treats

Answer 25

Anemia