Receptor Morpholgy And Function Flashcards
What are the two different types of receptors?
Cell surface and intracellular receptors
Define a receptor
A molecule that recognises specifically a second molecule, and response to a ligand brings about regulation of a cellular process
What is a ligand
A ligand is a molecule that binds specifically to a intracellular receptor site
What are the two types of ligand?
Agnoists and antagonists
What is an agnoist?
A lignad that binds and brings about activation of the receptor
What is a anatagonist?
A ligand that binds with a receptor site without producing a response, is a antagonist at it opposes the actions of a angoist.
Name some of the roles of receptors in cellular physiology
Singalling by hormones, release of intracellular calcium stores, cell adhesion, modulion of the immune response, neurotransmission, cellular delivery,
What are the four different types of receptor?
Membrane bound receptors with integral ion channels, membrane bound recpetors within ion channels, membrane bound receptors which couple to effectors though transuducing, intracellular receptors.
What are some examples of receptors assoicated with ion channels?
GABA receptor, Nitconic acetylcholine receptors, IP3 receptors, glycine receprptor gated chloride channel, glutamate receptors.
What are some key features of a G protein coupled receptor?
7 transmembrane domains, you can have intergarted signalling by inhibitory and stimulatory receptors that act on the same receptor, There is a G subunit and a By subunit that remain together.
Describe the mechanism of action of intracellular receptors.
An inhibitory protein blocks the dna binding site on the receptor, which is found in a L shape, the steroid hormone binds causing dissociation of the inhibitory protein and the hinge region straightens so that the receptor can attach to DNA.
What are the different types of signalling?
Singalling by secreted molecules (paracrine, endocrine and synaptic0 and signalling by plasma membrane bound molecules
