Receptor Medited Endocytosis

Question 1

What is the mechanism of vesicular transport?

Answer 1

Bud from the organelle, go to the receptor and fuse with the recepient organelle

Question 2

What are the three types of membrane internalisation?

Answer 2

Pinocytosis, phagocytosis, endocytosis

Question 3

What is pinocytosis?

Answer 3

the uptake of extracellular solute by the invagination of plasma membrane.

Question 4

What is the mechanism used in phagocytosis?

Answer 4

Zippering

Question 5

What does CURL mean?

Answer 5

Compartment of Uncoupling of receptor and ligand

Question 6

Why does the endosome have a lower pH?

Answer 6

H+ is actively pumped into the endosome

Question 7

What is a triskleion

Answer 7

Coat structures made of hexagons and pentagons, compose 3 clathrin heavy chains nd three clathrin light chains, hexagonal and pentagonal structures are formed by the triskelions

Question 8

How is the clathrin coat assembled?

Answer 8

Clatrhin coated pit form spontaneously, latrihrin triskelions are recycled back to the newly formed clathrin pits, and clatrhin coated vesicle sare uncoded by an ATP dependant uncoating protein.

Question 9

What is the fate of the receptor and the ligand in cholestrol endocytosis?

Answer 9

The ligand is degraded and the receptor s recycled

Question 10

What is the fate of the lignad and receptor in the uptke of Fe3+

Answer 10

The ligand and the receptor are both recycled

Question 11

wht re the two molecules involved in the reeptor mediated endocytosis of Fe3+

Answer 11

Ferrotrasnferrin and apotransferrin

Question 12

What s the fate of the ligand and the receptor in the endocytosis of immunoglobin

Answer 12

The lignad and the receptor are both transported

Question 13

What are the three different types of caot proteins?

Answer 13

Clathrin, COP I in the endoplasmic reticulum and COPII in the endoplasmic reticulum

Question 14

What are some of the mechanisms that membrane enveloped virsuses take advantge of?

Answer 14

They bind to cells by fortuitous association with the cell membrane, and the virsses take advantage of receptor mediated endocytosis, the unfold hydrophobic domains during membrane fusion, the insert membrane fusion proteins into the endosome membrane, and use the host cell machinery for the replication of RNA

Question 15

Which toxins enter via the process of receptor mediated endocytosis?

Answer 15

Cholera toxin, diphtheria toxin and can bind GM1 ganglioside

Question 16

Why is endocytosis important for the cell membrane?

Answer 16

Membrane is produced from the endoplasmic reticulum in the secretory pathway, and since membranes do not become ruffled normally, opposite movement is needed by the process of endocytosis.